701917-03-5

Basic information

• Product Name: 4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid
• Synonyms: 4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid;4-nitro-1-phenyl-1H-pyrazole
• CAS NO: 701917-03-5
• Molecular Formula: C₁₀H₇N₃O₄
• Molecular Weight: 233.18028
• EINECS: -0
• Mol File: 701917-03-5.mol

Chemical Properties

• Boiling Point: 455.1±30.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.33±0.41(Predicted)
• CAS DataBase Reference: 4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid(701917-03-5)
• EPA Substance Registry System: 4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid(701917-03-5)

Safety Data

• Hazardous Substances Data: 701917-03-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid is used as a key intermediate in the synthesis of various bioactive compounds. Its unique structure and functional groups make it a valuable building block for the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Development:
4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid also has applications in the agrochemical industry, where it can be used as a starting material for the synthesis of novel agrochemicals. Its reactivity and chemical properties allow for the creation of new compounds with potential use in crop protection and pest control.
Used in Materials Science:
4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid is utilized in materials science for the development of functional materials. Its versatile chemical properties enable the synthesis of new materials with specific properties, such as improved stability, reactivity, or selectivity, which can be applied in various industries.
Used in Organic Synthesis:
As a yellow crystalline solid with a unique structure, 4-Nitro-1-phenyl-1H-pyrazole-3-carboxylic acid serves as a valuable intermediate in organic synthesis. Its presence in various chemical reactions allows for the formation of a wide range of organic compounds, expanding the scope of chemical research and development.

Upstream product

• 28663-68-5 ethyl (phenylhydrazono)chloroacetate 
• 62-53-3 aniline 
• 21443-84-5 ethyl 4-nitro-1-phenylpyrazole-3-carboxylate 
• 98-80-6 phenylboronic acid 
• 701917-02-4 4-nitro-1-phenyl-1H-pyrazole-3-carboxylic acid methyl ester 

Downstream Products

• 701917-04-6 3-amino-4-nitro-1-phenyl-1H-pyrazole 
• 913739-29-4 tert-butyl (3-amino-1-phenyl-1H-pyrazol-4-yl)carbamate 
• 936755-48-5 2-naphthyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate 
• 936755-55-4 tert-butyl {3-[(4-{1,1-difluoro-2-[2-(2-methoxybenzoyl)hydrazino]-2-oxoethyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate 
• 936755-56-5 tert-butyl {3-[(4-{difluoro[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}benzoyl)amino]-1-phenyl-1H-pyrazol-4-yl} carbamate 
• 936755-57-6 tert-butyl 4-(5-{[(4-nitro-1-phenyl-1H-pyrazol-3-yl)amino]carbonyl}pyridin-2-yl)piperazine-1-carboxylate 
• 936755-30-5 benzyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate 
• 936755-29-2 tert-butyl (3-{[4-(aminomethyl)benzoyl]amino}-1-phenyl-1H-pyrazol-4-yl)carbamate 
• 936755-47-4 pyridin-3-ylmethyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate 

Relevant articles and documents

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This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

NITROGEN CONTAINING HETEROARYL COMPOUNDS

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NITROGEN CONTAINING HETEROARYL COMPOUNDS

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HISTONE DEACETYLASE INHIBITORS WITH ARYL-PYRAZOLYL MOTIFS

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The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the modified malonate derivatives in vivo.

Spirocyclic compounds

The present invention relates to a novel class of substituted spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of n

SUBSTITUTED NICOTINAMIDE COMPOUNDS

The present invention relates to a novel class of substituted nicotinamides.. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplast