701965-63-1Relevant academic research and scientific papers
Psoralen derivatives as inhibitors of NF-κB/DNA interaction: the critical role of the furan ring
Marzaro, Giovanni,Lampronti, Ilaria,Borgatti, Monica,Manzini, Paolo,Gambari, Roberto,Chilin, Adriana
, p. 551 - 561 (2015)
Abstract: Simplified analogues of previously reported NF-κB/DNA interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF-κB. Graphical abstract: [Figure not available: see fulltext.]
