701976-77-4

Upstream product

• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 628281-01-6 allyl (methyl 3-O-benzyl-α-L-idopyranosyluronate)-(1->4)-O-2-azido-3-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 87327-03-5 methyl (2,4-di-O-acetyl-3-O-benzyl-α-L-idopyranosyl bromide)uronate 

Downstream Products

• 628280-86-4 allyl [methyl 2-O-acetyl-3-O-benzyl-4-O-(4-methoxybenzyl)-α-L-idopyranosyluronate]-(1->4)-O-6-O-acetyl-2-azido-3-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 701976-82-1 (2R,3S,4R,5R,6R)-6-((2R,3S,4R,5R,6S)-6-Allyloxy-5-azido-4-benzyloxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy)-4-benzyloxy-5-hydroxy-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

PhBCl2 promoted reductive opening of 2′,4′-O-p- methoxybenzylidene: New regioselective differentiation of position 2′ and 4′ of α-L-iduronyl moieties in disaccharide building blocks

We describe a new protocol for the challenging differentiation of the position 2′ and 4′ of L-iduronyl moieties located at the nonreducing end of various disaccharide building blocks. This methodology is based on the introduction of a 2′,4 ′-O-p-methoxybenzylidene group, followed by a totally regioselective reductive opening of this acetal by the PhBCl2/Et 3SiH reagent system. L-Iduronyl moieties protected by a 4 ′-O-p-methoxybenzyl group were thus obtained regioselectively and efficiently.