70200-04-3Relevant academic research and scientific papers
Silver-catalyzed radical fluorination of alkylboronates in aqueous solution
Li, Zhaodong,Wang, Zhentao,Zhu, Lin,Tan, Xinqiang,Li, Chaozhong
, p. 16439 - 16443 (2015/01/09)
We report herein an efficient and general method for the deboronofluorination of alkylboronates. Thus, with the catalysis of AgNO3, the reactions of various alkylboronic acids or their pinacol esters with Selectfluor reagent in acidic aqueous solution afforded the corresponding alkyl fluorides under mild conditions. A broad substrate scope and wide functional group compatibility were observed. A radical mechanism is proposed for this site-specific fluorination.
Metal-catalyzed benzylic fluorination as a synthetic equivalent to 1,4-conjugate addition of fluoride
Bloom, Steven,Sharber, Seth Andrew,Holl, Maxwell Gargiulo,Knippel, James Levi,Lectka, Thomas
, p. 11082 - 11086 (2013/11/19)
We explore in detail the iron-catalyzed benzylic fluorination of substrates containing aromatic rings and electron-withdrawing groups positioned β to one another, thus providing direct access to β-fluorinated adducts. This operationally convenient process can be thought of not only as a contribution to the timely problem of benzylic fluorination but also as a functional equivalent to a conjugate addition of fluoride, furnishing products in moderate to good yields and in excellent selectivity.
