70200-06-5Relevant academic research and scientific papers
Metal-catalyzed benzylic fluorination as a synthetic equivalent to 1,4-conjugate addition of fluoride
Bloom, Steven,Sharber, Seth Andrew,Holl, Maxwell Gargiulo,Knippel, James Levi,Lectka, Thomas
, p. 11082 - 11086 (2013)
We explore in detail the iron-catalyzed benzylic fluorination of substrates containing aromatic rings and electron-withdrawing groups positioned β to one another, thus providing direct access to β-fluorinated adducts. This operationally convenient process can be thought of not only as a contribution to the timely problem of benzylic fluorination but also as a functional equivalent to a conjugate addition of fluoride, furnishing products in moderate to good yields and in excellent selectivity.
