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6-Methylthiopurine ribonucleoside-5'-phosphate, also known as 6-Methylthiopurine Ribonucleotide, is a chemical compound derived from the modification of purine nucleosides. It plays a significant role in the assessment of certain biological processes and has potential applications in the pharmaceutical industry.
Used in Pharmaceutical Industry:
6-Methylthiopurine Ribonucleotide is used as a diagnostic agent for the assessment of Thiopurine Methyltransferase (TPMT) activity and metabolite formation during Thiopurine Therapy. This is crucial for determining the appropriate dosage and monitoring the effectiveness of treatments involving thiopurine drugs, which are commonly used for various conditions, including inflammatory bowel disease and leukemia.
By measuring the levels of 6-Methylthiopurine Ribonucleotide, healthcare professionals can evaluate a patient's TPMT enzyme activity, which is essential for the metabolism of thiopurine drugs. This information helps in tailoring the treatment to individual patients, minimizing the risk of adverse effects and maximizing therapeutic outcomes.

7021-52-5

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7021-52-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7021-52-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,2 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7021-52:
(6*7)+(5*0)+(4*2)+(3*1)+(2*5)+(1*2)=65
65 % 10 = 5
So 7021-52-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N4O7PS/c1-4-13-9-6(10(24)14-4)12-3-15(9)11-8(17)7(16)5(22-11)2-21-23(18,19)20/h3,5,7-8,11,16-17H,2H2,1H3,(H,13,14,24)(H2,18,19,20)/t5-,7-,8-,11-/m1/s1

7021-52-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-methylmercaptopurine riboside 5'-monophosphate

1.2 Other means of identification

Product number -
Other names 6-methylmercaptopurine riboside 5'phosphate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7021-52-5 SDS

7021-52-5Downstream Products

7021-52-5Relevant academic research and scientific papers

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase

Krynetski, Eugene Y.,Krynetskaia, Natalia F.,Yanishevski, Yuri,Evans, William E.

, p. 1141 - 1147 (2007/10/03)

Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism, catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-methylated nucleobases that are inactive, whereas S-methylated nucleotides of these thiopurines are cytotoxic. A yeast- based heterologous expression system was therefore used to characterize human TPMT-catalyzed methylation of MP, TG, and their principal nucleotide metabolites [thioinosine monophosphate (TIMP) and thioguanosine monophosphate (TGMP), respectively]. MP, TG, TIMP, and TGMP were all substrates for human TPMT, exhibiting similar Michaelis-Menten kinetic parameters (K(m), 10.6- 27.1 μM; V(max), 31-59 nmol/min/mg of TPMT). Consistent with these kinetic parameters, human leukemia cells (CEM) incubated for 24 hr with 10 μM MP or TG accumulated significantly higher (2.3-fold, p = 0.01) concentrations of methyl-TIMP after MP incubation than methyl-TGMP after TG incubation, due to the 2.7-fold higher concentration of TIMP after MP incubation, compared with TG nucleotides (TGN) after TG incubation. Moreover, intracellular accumulation of TGN was 2.5-fold greater after TG incubation than after MP incubation (p = 0.01). These data establish that MP, TG, and their principal nucleotide metabolites are comparable substrates for polymorphic TPMT, and they demonstrate significant differences in the accumulation of active TGN and methylated nucleotides when leukemia cells are treated with MP versus TG.

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