70218-66-5Relevant academic research and scientific papers
Derivatives of (R) and (S)-2-amino-1-butanol as possible anti-arrhythmics
Kumar, G. Biju,Shah, A. C.
, p. 79 - 82 (2007/10/03)
The chiral imines derived from (R) and (S)-2-amino-1-butanol have been reported.Some of the chiral imines have been found to be in equilibrium with the corresponding 1,3-oxazolidines, which on treatment with sodium borohydride in methanol are reduced to the corresponding N-benzyl derivatives.
Process for resolving DL-Mandelic acid with novel 2-benzylamino-1-butanols
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, (2008/06/13)
A process for resolving DL-Mandelic acid which comprises reacting at moderately elevated temperatures in a two-phase liquid mixture of water and a suitable water-immiscible organic solvent about equimolecular amounts of DL-Mandelic acid and an optically active 2-benzylamino-1-butanol, represented by formula (I), STR1 to form a crude mandelate salt, represented by formula (II), STR2 wherein X is chloro, bromo, fluoro, or nitro; said crude mandelate salt is recovered and purified by contact with a suitable solvent to obtain an optically pure mandelate salt, represented by formula (II); the optically active mandelate salt is hydrolyzed with aqueous sodium or potassium hydroxide in a two-phase liquid mixture to obtain an organic phase containing an optically active compound of formula (I) and an alkalized aqueous phase containing the sodium or potassium salt of an optically active mandelic acid. The latter is acidified and an optically active mandelic acid is recovered therefrom.
