70229-07-1Relevant academic research and scientific papers
Base-controlled selectivity in the synthesis of linear and angular fused quinazolinones by a palladium-catalyzed carbonylation/nucleophilic aromatic substitution sequence
Chen, Jianbin,Natte, Kishore,Spannenberg, Anke,Neumann, Helfried,Langer, Peter,Beller, Matthias,Wu, Xiao-Feng
supporting information, p. 7579 - 7583 (2014/08/05)
A new approach for the facile synthesis of fused quinazolinone scaffolds through a palladium-catalyzed carbonylative coupling followed by an intramolecular nucleophilic aromatic substitution is described. The base serves as the key modulator: Whereas DBU gives rise to the linear isomers, Et 3N promotes the preferential formation of angular products. Interestingly, a light-induced 4+4 reaction of the product was also observed.
