7023-80-5

Basic information

• Product Name: Ethanone, 2-diazo-1-(3-methylphenyl)-
• CAS NO: 7023-80-5
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Mol File: 7023-80-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-diazo-1-(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-diazo-1-(3-methylphenyl)-(7023-80-5)
• EPA Substance Registry System: Ethanone, 2-diazo-1-(3-methylphenyl)-(7023-80-5)

Safety Data

• Hazardous Substances Data: 7023-80-5(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-diazo-1-(3-methylphenyl)-, also known as acetophenone diazomethane, is a diazo compound with the chemical formula C9H8N2O. It is a yellow to orange solid that is highly reactive and can be explosive. Ethanone, 2-diazo-1-(3-methylphenyl)- is primarily used in organic synthesis as a reagent for the introduction of the diazo functionality into organic molecules. It is also utilized in the preparation of other organic compounds, such as pyrazoles and hydrazines, through diazo transfer reactions. Due to its highly reactive nature, acetophenone diazomethane must be handled with extreme caution and under controlled conditions.

Upstream product

• 59826-44-7 1,3-di-(m-tolyl)propane-1,3-dione 
• 99-04-7 m-Toluic acid 
• 186581-53-3 diazomethane 
• 1711-06-4 3-Methylbenzoyl chloride 

Downstream Products

• 90765-38-1 3-methylphenylacetamide 
• 94327-90-9 (5-anilino-[1,2,3]thiadiazol-4-yl)-m-tolyl-methanone 
• 69163-83-3 2-methyl-5-(3′-methylphenyl)oxazole 
• 93263-08-2 α-Chlor-β-oxo-β-(3-methyl-phenyl)-thiopropionsaeure-chlorid 
• 21886-54-4 3-methylphenyl chloromethyl ketone 
• 621-36-3 m-methylphenylacetic acid 
• 121612-23-5 m-methyl-α-hydroxyacetophenone 
• 448922-65-4 2-diazo-1-(3'-methylphenyl)-2-(triisopropylsilyl)ethanone 
• 195137-31-6 1-(3-methylphenyl)pentane-1,4-dione 
• 55755-17-4 2-(3-methylphenyl)ethylamine 
• 1419101-61-3 (5,6-dimethoxy-3-methyl-1H-indol-2-yl)(m-tolyl)methanone 
• 1419101-63-5 1-(2-methyl-5-m-tolyl-1H-pyrrol-3-yl)ethanone 

Relevant articles and documents

Phosphoric Acid Catalyzed [4 + 1]-Cycloannulation Reaction of ortho-Quinone Methides and Diazoketones: Catalytic, Enantioselective Access toward cis-2,3-Dihydrobenzofurans

A highly straightforward route to enantiomerically highly enriched cis-2,3-dihydrobenzofurans has been achieved via addition of α-diazocarbonyl compounds to in situ generated o-QMs catalyzed by a chiral Br?nsted acid. This catalytic strategy provides a direct access to 2,3-dihydrobenzofurans in high yields and with up to 91:9 dr and 99:1 er at ambient temperature. Moreover, a unique phenonium-type rearrangement accounts for product formation with an inverted 2,3-substitution pattern.

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.