70230-68-1

Basic information

• Product Name: 5-(Methylamino)-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)imidazole-4-carboxamide
• Synonyms: 5-(Methylamino)-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)imidazole-4-carboxamide
• CAS NO: 70230-68-1
• Molecular Weight: 542.635
• Mol File: 70230-68-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(Methylamino)-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)imidazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Methylamino)-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)imidazole-4-carboxamide(70230-68-1)
• EPA Substance Registry System: 5-(Methylamino)-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)imidazole-4-carboxamide(70230-68-1)

Safety Data

• Hazardous Substances Data: 70230-68-1(Hazardous Substances Data)

Upstream product

• 2620-62-4 N,N-dimethyladenosine 
• 3181-38-2 2',3',5'-tri-O-acetylinosine 
• 70230-66-9 2',3',5'-tri-O-benzyl-N,N-dimethyladenosine 
• 70230-67-0 2',3',5'-tri-O-benzyl-N,N,3-trimethyladenosine iodide 

Downstream Products

• 132366-90-6 4,9-Dihydro-4,6-dimethyl-9-oxo-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-3H-imidazo<1,2-a>purine-7-carboxaldehyde 
• 132366-91-7 3,4-Dihydro-7-(hydroxymethyl)-4,6-dimethyl-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-9H-imidazo<1,2-a>purin-9-one 
• 132366-95-1 3,4-Dihydro-4,6-dimethyl-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-9H-imidazo<1,2-a>purin-9-one 
• 132366-89-3 2',3',5'-Tri-O-benzyl-3-methylguanosine 
• 132366-88-2 5-(Cyanomethylamino)-1-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide 
• 70230-69-2 2',3',5'-tri-O-benzyl-3-methylinosine 

Relevant articles and documents

Synthesis of 5-(Methylamino)-1-β-D-ribofuranosylimidazole-4-carboxamide, a Synthetic Intermediate for 3-Methyl-9-β-D-ribofuranosylpurines

Treatment of 2',3',5'-tri-O-benzoyl-N,N-dimethyladenosine (2c) with methyl iodide in AcNMe2 gave the 3-methyl derivative (3c) as a sole product.Alkaline hydrolysis of 3c afforded the title imidazolecarboxamide (4a), whose hydroxy groups were acetylated selectively with Ac2O-pyridine.Similar methylation of 2',3',5'-tri-O-benzyl-N,N-dimethyladenosine (2d) followed by alkaline hydrolysis provided 2',3',5'-tri-O-benzyl-4a (4d) in good yield.