70243-93-5

Basic information

• Product Name: 3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinolin-6(2H)-one
• CAS NO: 70243-93-5
• Molecular Weight: 199.252
• Mol File: 70243-93-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinolin-6(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinolin-6(2H)-one(70243-93-5)
• EPA Substance Registry System: 3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinolin-6(2H)-one(70243-93-5)

Safety Data

• Hazardous Substances Data: 70243-93-5(Hazardous Substances Data)

Upstream product

• 39911-06-3 1-[2'-(piperidin-1''-yl)phenyl]ethan-1-one 

Relevant articles and documents

Participation of electrophilic groups with the dehydrogenation of 4-substituted piperidines

Dehydrogenation of 2-(1-piperidinyl)-benzaldehydes 1-3 using mercury(II)-EDTA generated the lactams 4-6, indicating a reversible reaction of a carbinolamine intermediate with the formyl group. The yields and oxidation rates decreased by 4-substitution in the piperidine moiety. The 2-(1-piperidinyl)-acetophenones 11, 16-19 showed a similar behavior with mercury(II)-EDTA but gave rise to a product pattern. The trans-benzoquinolizidones 12, 20, 23, 26, 29 resulted from the cyclic iminium compounds reacting with the acetyl group as nucleophile. By another oxidation these species were partially transformed to the quinolinones 13, 21, 24, 27, 30. An intermediate electrophilic neighboring of the carbonyl group with the cyclic hemiaminals led finally to the lactams 14, 22, 25, 28, 31. Mechanisms for the reactions are proposed.