70256-30-3Relevant articles and documents
Syntheses, analgetic activity, and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives
Yokoyama,Almaula,Block,Granat,Gottfried,Hill,McMahon,Munch,Rachlin,Saelens,Siegel,Tomaselli,Clarke
, p. 537 - 553 (1979)
The synthesis, analgetic activity, and physical dependent capacity of a large number of 5-phenyl-6,7-benzomorphan derivatives are described. Observations made during the Stevens' rearrangement of 1-benzyl-1-methyl-Δ3-piperidinium salt derivatives (V) under various conditions are discussed. The absolute configuration of the 9-dimethyl series and the 2'-deoxy series is established by comparison of their ORD and CD spectra with those of ι-β-2'-hydroxy-2,9-dimethyl-5-phenyl-6,7-benzomorphan, whose absolute configuration was previously established by X-ray crystallography. A convenient synthesis of 3H-labeled phenols using 3H3PO4 is described, as well as the preparation of 14C-labeled compounds by conventional methods.