70259-96-0Relevant academic research and scientific papers
Thiol Reactivity of N-Aryl α-Methylene-γ-lactams: A Reactive Group for Targeted Covalent Inhibitor Design
Erbay, Tu??e G.,Dempe, Daniel P.,Godugu, Bhaskar,Liu, Peng,Brummond, Kay M.
, p. 11926 - 11936 (2021/09/02)
Kinase activity can be modulated reversibly or irreversibly by the reaction of targeted covalent inhibitors with nucleophilic residues in protein active sites. Herein, we present thiol reactivity studies that support α-methylene-γ-lactams as tunable surro
