702662-50-8
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Basic information
- Product Name: STING agonist-1
- Synonyms: STING agonist-1
- CAS NO:702662-50-8
- Molecular Formula: C21H16ClFN2O3S
- Molecular Weight: 430.8797432
- EINECS: N/A
- Product Categories: API
- Mol File: 702662-50-8.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 668.3±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.428±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 13.53±0.20(Predicted)
- CAS DataBase Reference: STING agonist-1(CAS DataBase Reference)
- NIST Chemistry Reference: STING agonist-1(702662-50-8)
- EPA Substance Registry System: STING agonist-1(702662-50-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 702662-50-8(Hazardous Substances Data)
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702662-50-8 Usage
Description
STING agonist-1, also known as G10, is an indirect activator of the stimulator of interferon genes (STING) signaling pathway. It induces the transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase the expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses.Used in Antiviral Applications:
STING agonist-1 is used as a novel human-specific STING agonist for eliciting antiviral activity against emerging Alphaviruses. It potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV), making it a promising candidate for the development of antiviral therapies against these viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 702662-50-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,2,6,6 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.Calculate Digit Verification of CAS Registry Number 702662-50:
(8*7)+(7*0)+(6*2)+(5*6)+(4*6)+(3*2)+(2*5)+(1*0)=138
138 % 10 = 8
So 702662-50-8 is a valid CAS Registry Number.
702662-50-8Upstream product
702662-50-8Downstream Products
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STING agonist-1
