702673-32-3Relevant academic research and scientific papers
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration
Drewry, David H.,Annor-Gyamfi, Joel K.,Wells, Carrow I.,Pickett, Julie E.,Dederer, Verena,Preuss, Franziska,Mathea, Sebastian,Axtman, Alison D.
, p. 1313 - 1328 (2021/08/24)
The pyrimidine core has been utilized extensively to construct kinase inhibitors, including eight FDA-approved drugs. Because the pyrimidine hinge-binding motif is accommodated by many human kinases, kinome-wide selectivity of resultant molecules can be p
CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS
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Page 118, (2008/06/13)
This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
