70268-36-9Relevant academic research and scientific papers
Sunfish amphiphiles: Conceptually new carriers for DNA delivery
Hulst, Ron,Muizebelt, Inouk,Oosting, Peter,Van Der Pol, Cornelia,Wagenaar, Anno,Smisterova, Jarmila,Bulten, Erna,Driessen, Cecile,Hoekstra, Dick,Engberts, Jan B. F. N.
, p. 835 - 849 (2007/10/03)
A conceptually new class of cationic amphiphiles, Sunfish amphiphiles, designed for the delivery of genes into cells is introduced. Sunfish amphiphiles have two hydrophobic tails, connected at the 4- and the N-position to the cationic pyridinium headgroup. Two extreme morphologies visualised by backfolding and combining of both tails at one site (matching situation) or unfolding of the tails at distinct interaction sites at biological membranes will lead to considerable differences in morphological behaviour. The underlying rationale allows controlled release by using this morphological alteration of the Sunfish/helper-lipid/DNA complex (lipoplex). The often-excellent transfection efficiencies are probably related to these morphological changes. In addition, the Sunfish amphiphiles possess low toxicities, resulting in high cell survival after internalisation. The underlying rationale, design, synthesis and in vitro transfection potential are discussed in detail. Moreover, some physico-chemical characteristics of the Sunfish amphiphiles have been studied. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
