70269-59-9Relevant academic research and scientific papers
The reaction of N-tosyl imines with heteroaromatic compounds: A new access to triheteroarylmethanes
Temelli, Baris,Tasgin, Dilek Isik,Unaleroglu, Canan
, p. 6765 - 6768 (2010)
Useful triheteroarylmethanes were prepared by the double Friedel-Crafts reaction of a wide variety of aromatic N-tosyl imines with furan, thiophene, and pyrrole in the presence of Cu(OTf)2 and Montmorillonite K-10 clay catalysts.
Aza-Morita-Baylis-Hillman reactions catalyzed by a cyclopropenylidene
Lu, Xun,Schneider, Uwe
supporting information, p. 12980 - 12983 (2016/11/09)
Catalysis using a bis(dialkylamino)cyclopropenylidene (BAC) has been developed, which relies on a formal umpolung activation of Michael acceptor pro-nucleophiles. Various aza-Morita-Baylis-Hillman reactions between aromatic, heteroaromatic, or aliphatic imines and acyclic or cyclic α,β-unsaturated ketones and carboxylic acid derivatives have been catalyzed by a BAC under mild conditions. Functionalities such as unprotected amino and hydroxy groups have been tolerated. The catalyst loading was decreased to 1 mol% without loss of activity. The BAC catalyst was shown to be substantially more active than a cyclic (alkyl)(amino) carbene (CAAC), N-heterocyclic carbenes (NHCs), and P- or N-centered Lewis bases.
