70276-66-3

Upstream product

• 70276-67-4 5-Fluor-2-(4-methylphenyl)-4-(trifluoromethyl)thiazol 
• 151-50-8 potassium cyanide 
• 57014-96-7 4-(p-Tolyl)-2,2-bis(trifluormethyl)-2H-1,3-thiazet 
• 57015-06-2 4-methyl-N-(2,2,2-trifluoro-1-trifluoromethyl-ethylidene)-thiobenzamide 

Downstream Products

• 128540-90-9 5-Aminomethyl-2-(4-methylphenyl)-4-trifluoromethylthiazole 
• 128540-95-4 N-<<2-(4-Methylphenyl)-4-trifluormethylthiazol-5-yl>-methyl>-harnstoff 
• 128540-97-6 N-<<2-(4-Methylphenyl)-4-trifluormethylthiazol-5-yl>-methyl>-N'-phenylthioharnstoff 
• 128540-98-7 N-<<2-(4-Methylphenyl)-4-trifluormethylthiazol-5-yl>methyl>-N'-ethoxycarbonylthioharnstoff 
• 128541-03-7 N-<(2-(4-Methylphenyl)-4-trifluormethylthiazol-5-yl)-methyl>-N'-tosylharnstoff 

Relevant academic research and scientific papers

5-Amino-4-trifluoromethylthiazoles and 5-Aminomethyl-4-trifluoromethyl-1,3-azoles: Useful Starting Materials for the Synthesis of Biologically Active Compounds

The title compounds are obtained from 5-fluoro-4-trifluoromethyl-1,3-azoles.Introduction of various side chains of potential biological interest at C-5 can be achieved with electrophiles by reaction of the amino group.

Reaction Behaviour of Trifluoromethyl Groups. Synthesis of 1,3-Azoles from Trifluoromethyl-substituted Hetero-1,3-dienes

4,4-Bis(trifluoromethyl)-substituted 1-oxa-3-aza-1,3-butadienes 1, 1-thia-3-aza-1,3-butadienes 2 as well as 1,3-diaza-1,3-butadienes 3 on heating with tin(II) chloride yield 5-fluoro-4-trifluoromethyl-substituted oxazoles 4, thiazoles 5, and imidazoles 6,