70289-12-2

Basic information

• Product Name: 2-ETHOXYPHENYLACETIC ACID
• Synonyms: RARECHEM AL BO 0335;O-ETHOXY PHENYL ACETIC ACID;2-ETHOXYPHENYLACETIC ACID
• CAS NO: 70289-12-2
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• Product Categories: Aromatic Phenylacetic Acids and Derivatives
• Mol File: 70289-12-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 103-104°C
• Boiling Point: 305 °C at 760 mmHg
• Flash Point: 119.3 °C
• Appearance: /
• Density: 1.144 g/cm³
• Vapor Pressure: 0.00037mmHg at 25°C
• Refractive Index: 1.53
• Solubility: soluble in Methanol
• PKA: 4.15±0.10(Predicted)
• CAS DataBase Reference: 2-ETHOXYPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXYPHENYLACETIC ACID(70289-12-2)
• EPA Substance Registry System: 2-ETHOXYPHENYLACETIC ACID(70289-12-2)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 70289-12-2(Hazardous Substances Data)

Usage

Uses

2-Ethoxyphenylacetic Acid is a versatile reactant used in various chemical syntheses that yield enzyme inhibitors. 2-Ethoxyphenylacetic Acid is used as a reactant in engineered myoglobins in which hemin iron is replaced by various abiological noble metals produce novel metalloenzymes that catalyze carbene insertion into C-H bonds as well as carbene addition to vinylarenes and aliph. α-olefins.

InChI:InChI=1/C10H12O3/c1-2-13-9-6-4-3-5-8(9)7-10(11)12/h3-6H,2,7H2,1H3,(H,11,12)

Upstream product

• 141-52-6 sodium ethanolate 
• 75-03-6 ethyl iodide 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 1189772-73-3 ethyl 2-(2-ethoxyphenyl)acetate 
• 74205-51-9 2-ethoxy benzylcyanide 
• 60906-78-7 1-chloromethyl-2-ethoxybenzene 
• 71672-75-8 2-ethoxybenzyl alcohol 
• 90-01-7 salicylic alcohol 

Downstream Products

• 1049093-89-1 2-(2-ethoxyphenyl)acetyl chloride 
• 139756-21-1 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one 
• 64055-53-4 2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one 
• 139756-22-2 5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 139755-83-2 viagra 
• 946583-63-7 C₂₆H₃₃ClN₂O₃ 
• 186019-68-1 methyl 2-(ethoxyphenyl)acetate 

Relevant articles and documents

Improved, gram-scale synthesis of sildenafil in water using arylacetic acid as the acyl source in the pyrazolo[4,3-d]pyrimidin-7-one ring formation

An improved, gram-scale synthesis of the blockbuster drug sildenafil, used for the treatment of male erectile dysfunction, has been developed. Unlike the previous literature, the current method demonstrates the use of arylacetic acid as an acyl source, a cheap oxidant K2S2O8, and water as the reaction medium in the key step of pyrrazolo[4,3-d]pyrimidin-7-one ring formation. As well as being a green and benign approach, the current method reduces the cost by half compared to our previous strategy. In addition, the general relevance of the method has been demonstrated in the synthesis of a variety of quinazolinone and benzothiazole derivatives with excellent functional group tolerance.