703-13-9

Usage

Uses

Used in Organic Synthesis:
Cyclopentyl trifluoroacetate is used as a reagent in the preparation of cyclopentyl glycolate esters, which are important intermediates in the synthesis of various pharmaceuticals and agrochemicals.
Used in Chemical Reactions:
Cyclopentyl trifluoroacetate is used as a solvent in various chemical reactions, facilitating the process and improving the yield of the desired products.
Used in Pharmaceutical Industry:
Cyclopentyl trifluoroacetate is used as a key intermediate in the synthesis of certain pharmaceutical compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
Cyclopentyl trifluoroacetate is used in the synthesis of agrochemicals, such as pesticides and herbicides, to help protect crops and improve agricultural productivity.

InChI:InChI=1/C7H9F3O2/c8-7(9,10)6(11)12-5-3-1-2-4-5/h5H,1-4H2

Upstream product

• 287-92-3 Cyclopentane 
• 201230-82-2 carbon monoxide 
• 76-05-1 trifluoroacetic acid 

Relevant academic research and scientific papers

Vanadium-catalyzed carboxylation of linear and cyclic C5 and C6 alkanes

Cyclopentane, cyclohexane, pentane, and hexane are carbonylated in single-pot processes and under mild conditions to carboxylic acids (highest yields of 54-33% and turnover numbers [TONs] of 76-50) by vanadium (IV) and (V) complexes in TFA. These complexes present N,O- or O,O-ligands, namely basic forms of aminoalcohols and of (hydroxyimino)dicarboxylic acids, trifluoroacetate, or triflate. The effects of various parameters (e.g., catalyst type, oxidizing agent, CO pressure, temperature, reaction time, type of solvent) were investigated. The use of either too low or too high CO pressures is discouraged, because the former promote the formation of trifluoroacetate esters and the latter, above a certain level, do not result in higher yields or TONs of the carboxylic acids. Carbon- and oxygen-centered radical mechanisms are suggested by experiments with radical traps and by acid product distribution.

Synthesis of carboxylic acids through the formation of C-C bond between saturated hydrocarbons and CO in the presence of Mg/K2S2O8/TFA system

Magnesium powder (Mg) promoted the carboxylation reaction of saturated hydrocarbons with carbon monoxide (CO) in the presence of potassium peroxodisulfate (K2S2O8) in trifluoroacetic acid (TFA) to yield the corresponding carboxylic acids and alkyl trifluoroacetates. About 80% conversion of cyclohexane was achieved when 5 mmol of magnesium, 5 mmol of potassium peroxodisulfate, 3 mL of TFA, 1 mmol of cyclohexane, 50 atm of CO were used at 80 °C for 30 h.

Cobalt catalyzed carboxylation reaction of saturated hydrocarbons with CO in the presence of K2S2O8 and TFA under mild conditions

Cobalt(II) acetate (Co(OAc)2) has been found to be an efficient catalyst for the carboxylation reaction of saturated hydrocarbons with CO to yield the corresponding carboxylic acids in high yields in the presence of K2S2O8 and CF3COOH. About 89.5% conversion of propane is obtained in this reaction. The activation parameters of the reaction of propane have been determined by Arrhenius and Eyring plots.