70312-01-5Relevant articles and documents
A new series of estrogen receptor modulators that display selectivity for estrogen receptor β
Henke, Brad R.,Consler, Thomas G.,Go, Ning,Hale, Ron L.,Hohman, Dana R.,Jones, Stacey A.,Lu, Amy T.,Moore, Linda B.,Moore, John T.,Orband-Miller, Lisa A.,Robinett, R. Graham,Shearin, Jean,Spearing, Paul K.,Stewart, Eugene L.,Turnbull, Philip S.,Weaver, Susan L.,Williams, Shawn P.,Wisely, G. Bruce,Lambert, Millard H.
, p. 5492 - 5505 (2007/10/03)
A series of 1,3,5-triazine-based estrogen receptor (ER) modulators that are modestly selective for the ERβ subtype are reported. Compound 1, which displayed modest potency and selectivity for ERβ vs ERα, was identified via high-throughput screening utiliz