70315-70-7

Basic information

• Product Name: 3-Iodo-6-nitroindazole
• Synonyms: 3-IODO-6-NITRO (1H)INDAZOLE;3-IODO-6-NITROINDAZOLE;3-Iodo-6-nitro-1H-indazole ,97%;1H-Indazole, 3-iodo-6-nitro-;3-iodo-6-nitro-2h-indazole;Axitinib Intermediate;Axitinib Intermediate 1
• CAS NO: 70315-70-7
• Molecular Formula: C₇H₄IN₃O₂
• Molecular Weight: 289.03
• Product Categories: Indazoles;Intermediate of Axitinib
• Mol File: 70315-70-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 259-261 °C
• Boiling Point: 458.027 °C at 760 mmHg
• Flash Point: 230.807 °C
• Appearance: /
• Density: 2.24
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.818
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.12±0.40(Predicted)
• CAS DataBase Reference: 3-Iodo-6-nitroindazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodo-6-nitroindazole(70315-70-7)
• EPA Substance Registry System: 3-Iodo-6-nitroindazole(70315-70-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-60
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 70315-70-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C7H4IN3O2/c8-7-5-2-1-4(11(12)13)3-6(5)9-10-7/h1-3H,(H,9,10)

Upstream product

• 7597-18-4 6-nitroindazole 
• 99-55-8 2-methyl-5-nitroaniline 

Downstream Products

• 586330-18-9 tert-butyl 3-iodo-6-nitro-1H-indazole-1-carboxylate 
• 858661-74-2 3-cyano-6-nitroindazole 
• 7597-18-4 6-nitroindazole 
• 885519-20-0 3-iodo-6-aminoindazole 
• 319460-85-0 axitinib 
• 885126-35-2 (E)-N-methyl-2-{[3-(2-(pyridin-2-yl)ethenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl]thio}benzamide 
• 1204771-03-8 Ethyl 2-(6-amino-3-phenyl-1H-indazol-1-yl)thiazole-4-carboxylate 
• 1204772-52-0 C₁₈H₁₄N₄O₂S 
• 1204771-90-3 C₁₇H₁₂N₄O₂S 
• 1204773-04-5 ethyl 2-(6-nitro-3-phenyl-1H-indazol-1-yl)thiazole-4-carboxylate 
• 1204772-11-1 ethyl 2-{6-(methylamino)-3-phenyl-1H-indazol-1-yl}thiazole-4-carboxylate 
• 1133966-21-8 (E)-methyl 7-oxo-7-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)heptanoate 
• 1133966-20-7 (E)-2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzenamine 
• 1133966-19-4 (E)-ethyl 6-oxo-6-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenylamino)hexanoate 

Relevant articles and documents

NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES

Disclosed herein are novel compounds that inhibit fructokinase (KHK or ketohexokinase) and the downstream metabolic effects mediated by fructose metabolism. Fructokinase inhibitors specifically block the metabolism of both dietary and endogenous fructose

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

N-indazole substituted thiourea derivatives and preparation method and application thereof

The invention discloses N-indazole substituted thiourea derivatives and a preparation method and application thereof and belongs to the technical field of chemical medicine.The thiourea derivatives are a series of compounds simultaneously containing the 1H-indazole ring structure and the asymmetrical thiourea structure, and the compounds are not reported in the literature.The bioactivity test result analysis of the thiourea derivatives show that the compounds are good in antioxidant activity, the average scavenging rate is above 80%, the scavenging rate of the compound 12b, the compound 12c, and the compound 12d and the compound 12h is higher than 90%, the scavenging activity IC50 of the compound 12h on DPPH is 0.14mg/mL; part of the target compounds has certain inhibition activity on herpes viruses, vaccinia viruses, reoviruses, Coxsackie viruses, Feline coronary herpes viruses, HIV viruses and the like, and the compound 12c and the compound 12n are high in antivirus activity; the synthesized compounds hopefully have new bioactivity which is not expounded, and a certain material basis is provided for the development of new medicine.