70321-33-4

Usage

Uses

Used in Pharmaceutical Industry:
2,3-dibromo-3-(2-nitrophenyl)propanoic acid is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable component in the development of new drugs and chemical products.
Used in Antibiotic Development:
2,3-dibromo-3-(2-nitrophenyl)propanoic acid is utilized as a starting material for the development of new antibiotics. Its strong antimicrobial properties contribute to the creation of effective treatments against bacterial infections.
Used in Antifungal Agent Development:
2,3-dibromo-3-(2-nitrophenyl)propanoic acid is also employed in the development of antifungal agents. Its potent antifungal properties help in formulating treatments for fungal infections, addressing the growing need for new antifungal drugs.
Used in Cancer Research:
2,3-dibromo-3-(2-nitrophenyl)propanoic acid is studied for its potential as an anti-cancer agent. Its ability to inhibit the growth of tumor cells makes it a promising candidate for further research and development in oncology.
Used in Agriculture:
In the agricultural sector, 2,3-dibromo-3-(2-nitrophenyl)propanoic acid is used for its antimicrobial and antifungal properties. It can be incorporated into pesticides and fungicides to protect crops from various diseases and pests, ensuring a healthy and productive agricultural yield.

Upstream product

• 612-41-9 2-nitrocinnamic acid 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 209259-55-2 (Z)-1-[2-bromovinyl]-2-nitrobenzene 
• 530-85-8 3-(2-nitrophenyl)-2-propynoic acid 
• 91-56-5 indole-2,3-dione 
• 856162-35-1 β-bromo-2-nitro-styrene 
• 482-89-3 1H,1H'-2,2'-Biindolylidene-3,3'-dione 
• 430434-56-3 (E)-1-[2-bromovinyl]-2-nitrobenzene 
• 120-72-9 indole 
• 1664-63-7 2-amino-cinnamic acid 
• 52670-38-9 2-ethynylaniline 
• 16433-96-8 2-ethynyl-1-nitrobenzene 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs

Research on thymidylate synthase inhibitors has been a hot spot for anticancer drug development. Here, based on the structures and pharmacological properties of two types of TS inhibitors, through a molecular assembly principle of drugs design, we designed and synthesized a series of 30 novel uracil derivatives as TS inhibitors. The antiproliferative ability of these compounds was evaluated against four cancer cell lines (A549, OVCAR-3, SGC-7901, and HepG2) by the MTT assay. Most of them showed excellent activities against all the tested cell lines. Furthermore, hTS assay results showed that these compounds have the unique ability to inhibit hTS activity in vitro. Notably, compound 13j exhibited the most potent activity against A549 cells (IC50 = 1.18 μM) and extremely prominent enzyme inhibition (IC50 = 0.13 μM), which was superior to the pemetrexed (PTX, IC50 = 3.29 μM and IC50 = 2.04 μM). Flow cytometric analysis showed the compound 13j could inhibit A549 cells proliferation by arresting the cell cycle in the G1/S phase, then induced the cell apoptosis. Further western blot analysis showed that compound 13j could down-regulate the cycle checkpoint proteins cyclin D1 and cyclin E to inhibit the cell cycle progression, and then induce intrinsic apoptosis by activating caspase-3, and reducing the ratio of bcl-2/bax. All of these results demonstrated that this new structure has potential drug-making properties and provides new ideas for drug development.

Chloro/bromotrimethylsilane-Cu(NO3)2·3H2O: Safe and efficient reagent system for the decarboxylative ipso-nitration and dibromination of cinnamic acids

Further synthetic potential of halotrimethylsilane-nitrate salt mixture is revealed. A mixture of TMSX-Cu(NO3)2·3H2O system is found to be an efficient reagent system for both the decarboxylative nitration (ipso-nitration) when X?=?Cl, and dibromination of cinnamic acids, with X?=?Br, under mild conditions. The reactions are safe and simple, affording the corresponding products (E)-β-nitrostyrenes, and anti-2,3-dibromo-3-phenylpropanoic acids in high yields with high selectivity in a relatively short time. Use of hazardous and toxic nitrating systems such as acetyl nitrate and brominating agents such as molecular bromine can be avoided.

Synthesis of (Z)-1-bromo-1-alkenes and terminal alkynes from anti-2,3-dibromoalkanoic acids by microwave-induced reaction

(Z)-1-Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time by microwave irradiation of the corresponding anti-2,3-dibromoalkanoic acids in a Et3N/DMF system. A one-pot synthesis of terminal alkynes and enynes from 2,3-dibromoalkanoic acids were also developed by microwave-induced reaction.

Convenient and stereoselective synthesis of (Z)-1-bromo-1-alkenes by microwave-induced reaction

(Z)-1-Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time (0.2-1.0 min) by microwave irradiation of the corresponding 2,3-dibromoalkanoic acids in DMF in the presence of triethylamine.

Synthesis of the Substituted Z-1-Bromo-1-alkenes and Arylacetylenes from 2,3-Dibromocarboxylic Acids

Stereoselectivity was studied of simultaneous debromination-decarboxylation of dibrominated cinnamic and acrylic acids. The best selectivity in formation of Z-vinyl bromides was achieved with the use of organic nitrogen bases. The 1-bromo-1-alkenes were converted into the corresponding acetylenes.