70328-12-0

Upstream product

• 13512-57-7 N-[(1,1-dimethylethoxycarbonyl)amino]-L-asparagine benzyl ester 
• 104-15-4 toluene-4-sulfonic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1027182-96-2 (2S,3S)-3-Benzyloxy-N-((S)-1-benzyloxycarbonyl-2-carbamoyl-ethyl)-2-hydroxy-succinamic acid methyl ester 
• 1026554-93-7 (2S,3S)-2-Benzyloxy-N-((S)-1-benzyloxycarbonyl-2-carbamoyl-ethyl)-3-hydroxy-succinamic acid methyl ester 
• 498563-48-7 (S)-4-[7-{5-[(S)-2-((S)-1-Benzyloxycarbonyl-2-carbamoyl-ethylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-2-methoxymethoxy-phenyl}-2-oxo-1,2-dihydro-indol-(3E)-ylidenemethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 1219835-31-0 N-((3S)-N-(Boc-L-asparaginyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-asparagine benzyl ester 
• 1185198-30-4 N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-asparagine benzyl ester 
• 1184612-51-8 benzyl (S)-2-aminocarbonylmethyl-2-(isoquinoline-3-carboxamido)acetate 
• 1675213-59-8 C₂₅H₄₀N₂O₄ 
• 945650-57-7 N-[(3S)-N-Boc-1,2,3,4-tetrahydro-β-carboline-3-carboxyl]-L-asparagine benzyl ester 
• 1025967-62-7 (2S,3S)-3-Benzyloxy-N-((S)-1-benzyloxycarbonyl-2-carbamoyl-ethyl)-2-hydroxy-succinamic acid 
• 498563-49-8 4-[(7-{5-[2-(1-benzyloxycarbonyl-2-carbamoyl-ethylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-2-methoxymethoxy-phenyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 132346-82-8 N²-(S-benzyl-L-cysteinyl)-L-asparagine benzyl ester 

Relevant academic research and scientific papers

Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules

The gene cluster responsible for synthesis of the unknown molecule colibactin has been identified in mutualistic and pathogenic Escherichia coli. The pathway endows its producer with a long-term persistence phenotype in the human bowel, a probiotic activity used in the treatment of ulcerative colitis, and a carcinogenic activity under host inflammatory conditions. To date, functional small molecules from this pathway have not been reported. Here we implemented a comparative metabolomics and targeted structural network analyses approach to identify a catalog of small molecules dependent on the colibactin pathway from the meningitis isolate E. coli IHE3034 and the probiotic E. coli Nissle 1917. The structures of 10 pathway-dependent small molecules are proposed based on structural characterizations and network relationships. The network will provide a roadmap for the structural and functional elucidation of a variety of other small molecules encoded by the pathway. From the characterized small molecule set, in vitro bacterial growth inhibitory and mammalian CNS receptor antagonist activities are presented.

A class of novel conjugates of substituted purine and Gly-AA-OBzl: Synthesis and evaluation of orally analgesic activity

Aimed at the chemotherapy of chronic pain two kinds of analgesic pharmacophores, substituted purine and Gly-AA-OBzl, were coupled via a five-step-reaction procedure and 19 novel conjugates N-[2-chloro-9- (tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycylamino acid benzylesters were provided. On mouse-tail flick model their in vivo analgesic activities were assayed. The results indicate that introducing Gly-OC2H 5 into the 6-position of the substituted purine leads to ambiguous increase of the analgesic activity, while introducing Gly-AA-OBzl into this position leads to significant increase of the analgesic activity.

[Asn2 ]-thymosin α1 and analogs thereof

Thymosin α1, was chemically synthesized by the fragment condensation of the protected amino terminal tetradecapeptide with the protected carboxyl terminal tetradecapeptide. Similarly prepared was the analog [Asn2 ]-thymosin α1 utilizing the appropriately modified protected amino terminal tetradecapeptide. Both products are active as agents which affect regulation, differentiation and function of thymus dependent lymphocytes (T cells).