70328-12-0

Basic information

• Product Name: L-Asparagine, phenylmethyl ester
• CAS NO: 70328-12-0
• Molecular Formula: C11H14N2O3
• Molecular Weight: 222.244
• Mol File: 70328-12-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Asparagine, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Asparagine, phenylmethyl ester(70328-12-0)
• EPA Substance Registry System: L-Asparagine, phenylmethyl ester(70328-12-0)

Safety Data

• Hazardous Substances Data: 70328-12-0(Hazardous Substances Data)

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 100-51-6 benzyl alcohol 
• 13512-57-7 N-[(1,1-dimethylethoxycarbonyl)amino]-L-asparagine benzyl ester 

Downstream Products

• 132346-82-8 N²-(S-benzyl-L-cysteinyl)-L-asparagine benzyl ester 
• 498563-48-7 (S)-4-[7-{5-[(S)-2-((S)-1-Benzyloxycarbonyl-2-carbamoyl-ethylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-2-methoxymethoxy-phenyl}-2-oxo-1,2-dihydro-indol-(3E)-ylidenemethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 1185198-30-4 N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-asparagine benzyl ester 
• 1675213-59-8 C₂₅H₄₀N₂O₄ 
• 1184612-51-8 benzyl (S)-2-aminocarbonylmethyl-2-(isoquinoline-3-carboxamido)acetate 
• 1219835-31-0 N-((3S)-N-(Boc-L-asparaginyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-asparagine benzyl ester 
• 1025967-62-7 (2S,3S)-3-Benzyloxy-N-((S)-1-benzyloxycarbonyl-2-carbamoyl-ethyl)-2-hydroxy-succinamic acid 
• 498563-49-8 4-[(7-{5-[2-(1-benzyloxycarbonyl-2-carbamoyl-ethylcarbamoyl)-2-tert-butoxycarbonylamino-ethyl]-2-methoxymethoxy-phenyl}-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 1026554-93-7 (2S,3S)-2-Benzyloxy-N-((S)-1-benzyloxycarbonyl-2-carbamoyl-ethyl)-3-hydroxy-succinamic acid methyl ester 
• 1027182-96-2 (2S,3S)-3-Benzyloxy-N-((S)-1-benzyloxycarbonyl-2-carbamoyl-ethyl)-2-hydroxy-succinamic acid methyl ester 
• 945650-57-7 N-[(3S)-N-Boc-1,2,3,4-tetrahydro-β-carboline-3-carboxyl]-L-asparagine benzyl ester 

Relevant articles and documents

Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules

The gene cluster responsible for synthesis of the unknown molecule colibactin has been identified in mutualistic and pathogenic Escherichia coli. The pathway endows its producer with a long-term persistence phenotype in the human bowel, a probiotic activity used in the treatment of ulcerative colitis, and a carcinogenic activity under host inflammatory conditions. To date, functional small molecules from this pathway have not been reported. Here we implemented a comparative metabolomics and targeted structural network analyses approach to identify a catalog of small molecules dependent on the colibactin pathway from the meningitis isolate E. coli IHE3034 and the probiotic E. coli Nissle 1917. The structures of 10 pathway-dependent small molecules are proposed based on structural characterizations and network relationships. The network will provide a roadmap for the structural and functional elucidation of a variety of other small molecules encoded by the pathway. From the characterized small molecule set, in vitro bacterial growth inhibitory and mammalian CNS receptor antagonist activities are presented.

[Asn2 ]-thymosin α1 and analogs thereof

Thymosin α1, was chemically synthesized by the fragment condensation of the protected amino terminal tetradecapeptide with the protected carboxyl terminal tetradecapeptide. Similarly prepared was the analog [Asn2 ]-thymosin α1 utilizing the appropriately modified protected amino terminal tetradecapeptide. Both products are active as agents which affect regulation, differentiation and function of thymus dependent lymphocytes (T cells).