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Lornoxicam
Cas No: 70374-39-9
No Data 1 Kilogram 1 Metric Ton/Month HANGZHOU YUNUO CHEMICAL CO.,LTD Contact Supplier
Lornoxicam Manufacturer/High quality/Best price/In stock
Cas No: 70374-39-9
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Good quality Lornoxicam 99%min at best price CAS NO.70374-39-9
Cas No: 70374-39-9
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Factory supply Lornoxicam Cas 70374-39-9 with high quality and reasonable price
Cas No: 70374-39-9
USD $ 1.5-2.0 / Gram 100 Gram 2 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Lornoxicam
Cas No: 70374-39-9
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
70374-39-9 Lornoxicam
Cas No: 70374-39-9
USD $ 10.0-20.0 / Gram 100 Gram 10 Metric Ton/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Factory Supply High Quality 99% Powder CAS 70374-39-9 Lornoxicam with Good Price
Cas No: 70374-39-9
USD $ 68.0-78.0 / Kilogram 1 Kilogram 5000 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Factory supply high quality Lornoxicam,70374-39-9
Cas No: 70374-39-9
No Data No Data Metric Ton/Day Hubei Taiho Chemical Co.,LTD Contact Supplier
Lornoxicam
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No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Lornoxicam
Cas No: 70374-39-9
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier

70374-39-9 Usage

References

https://www.drugbank.ca/drugs/DB06725
https://en.wikipedia.org/wiki/Lornoxicam

Uses

keratolytic, antiacne, antineoplastic

Uses

Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic

Definition

ChEBI: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for th treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.

Uses

ocular vasoconstrictor

Chemical Properties

Crystalline Solid

Description

Lornoxicam (Trade name: “Xefo”) belongs to a non-steroidal anti-inflammatory drug. As a kind of oxicam class drug, it has analgesic, anti-inflammatory and antipyretic properties. It can be used for the treatment of various type of acute mild to moderate pain which results from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and rheumatic diseases. Lornoxicam is capable of potently inhibiting the prostaglandin biosynthesis process, making it have highly pronounced efficacy. The exact mechanism of Lornoxicam is not exactly understood. However, it is indicated that Lornoxicam can inhibit the prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2, leading to reduction of inflammation, pain, fever, and swelling.

Uses

For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.
InChI:InChI=1/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)

70374-39-9 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (SML0338)  Lornoxicam  ≥98% (HPLC) 70374-39-9 SML0338-50MG 3,261.96CNY Detail
Sigma (SML0338)  Lornoxicam  ≥98% (HPLC) 70374-39-9 SML0338-10MG 803.79CNY Detail
TCI America (L0239)  Lornoxicam  >98.0%(HPLC)(N) 70374-39-9 5g 2,650.00CNY Detail
TCI America (L0239)  Lornoxicam  >98.0%(HPLC)(N) 70374-39-9 1g 880.00CNY Detail

70374-39-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name lornoxicam

1.2 Other means of identification

Product number -
Other names Safem

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:70374-39-9 SDS

70374-39-9Synthetic route

C14H14ClN3O5S2

C14H14ClN3O5S2

lornoxicam
70374-39-9

lornoxicam

Conditions
ConditionsYield
With sodium methylate for 2h; Reflux;87%
2-aminopyridine
504-29-0

2-aminopyridine

lornoxicam
70374-39-9

lornoxicam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / Large scale
1.2: 1 h / 20 °C / Large scale
2.1: triethylamine / ethyl acetate / 0 - 20 °C / Large scale
3.1: sodium methylate / 2 h / Reflux
View Scheme
lornoxicam
70374-39-9

lornoxicam

methanesulfonic acid
75-75-2

methanesulfonic acid

lornoxicam mesylate
1608472-15-6

lornoxicam mesylate

Conditions
ConditionsYield
In ethanol for 1h; Milling;96%
lornoxicam
70374-39-9

lornoxicam

cobalt(II) tetrafluoroborate hexahydrate
15684-35-2

cobalt(II) tetrafluoroborate hexahydrate

glycine
56-40-6

glycine

[Co(lornoxicam)2(glycine)]BF4

[Co(lornoxicam)2(glycine)]BF4

Conditions
ConditionsYield
In ethanol for 2h; Reflux;96%
piperazine
110-85-0

piperazine

lornoxicam
70374-39-9

lornoxicam

lornoxicam piperazinium salt

lornoxicam piperazinium salt

Conditions
ConditionsYield
In ethanol for 1h; Milling;95%
lornoxicam
70374-39-9

lornoxicam

chromium(III) chloride hexahydrate

chromium(III) chloride hexahydrate

glycine
56-40-6

glycine

[Cr(lornoxicam)2(glycine)]Cl2*3H2O

[Cr(lornoxicam)2(glycine)]Cl2*3H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;95%
lornoxicam
70374-39-9

lornoxicam

iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

glycine
56-40-6

glycine

[Fe(lornoxicam)(glycine)(H2O)2]Cl2*H2O

[Fe(lornoxicam)(glycine)(H2O)2]Cl2*H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;95%
lornoxicam
70374-39-9

lornoxicam

lornoxicam hydrochloride

lornoxicam hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 0.75h; Milling;93%
lornoxicam
70374-39-9

lornoxicam

nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

glycine
56-40-6

glycine

[Ni(lornoxicam)2(glycine)]Cl

[Ni(lornoxicam)2(glycine)]Cl

Conditions
ConditionsYield
In ethanol for 2h; Reflux;93%
lornoxicam
70374-39-9

lornoxicam

iron(II) tetrafluoroborate hexahydrate

iron(II) tetrafluoroborate hexahydrate

glycine
56-40-6

glycine

[Fe(lornoxicam)(glycine)(H2O)2]BF4*H2O

[Fe(lornoxicam)(glycine)(H2O)2]BF4*H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;93%
lornoxicam
70374-39-9

lornoxicam

lornoxicam ammonium salt
1608472-18-9

lornoxicam ammonium salt

Conditions
ConditionsYield
With ammonium hydroxide In ethanol; water for 0.75h; Milling;92%
lornoxicam
70374-39-9

lornoxicam

copper(II) tetrafluroborate hexahydrate

copper(II) tetrafluroborate hexahydrate

glycine
56-40-6

glycine

[Cu(lornoxicam)2(glycine)]BF4*2H2O

[Cu(lornoxicam)2(glycine)]BF4*2H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;91%
lornoxicam
70374-39-9

lornoxicam

dimethyltin oxide
2273-45-2

dimethyltin oxide

[SnMe2(lornoxicam)]

[SnMe2(lornoxicam)]

Conditions
ConditionsYield
In benzene Sn compd. added to soln. of ligand, refluxed for 7 h; evapd. in vac., chilled, triturated with Et2O, redissolved in Et2O (repeated twice), filtered, dried in vac. over silica gel, elem. anal.;90%
lornoxicam
70374-39-9

lornoxicam

manganese(II) chloride dihydrate

manganese(II) chloride dihydrate

glycine
56-40-6

glycine

[Mn(lornoxicam)2(glycine)]Cl*H2O

[Mn(lornoxicam)2(glycine)]Cl*H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;89%
lornoxicam
70374-39-9

lornoxicam

zinc tetrafluoroborate

zinc tetrafluoroborate

glycine
56-40-6

glycine

[Zn(lornoxicam)2(glycine)]BF4*2H2O

[Zn(lornoxicam)2(glycine)]BF4*2H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;87%
lornoxicam
70374-39-9

lornoxicam

N,N-dimethyl-γ-aminobutyric acid chloride hydrochloride

N,N-dimethyl-γ-aminobutyric acid chloride hydrochloride

6-chloro-4-(N,N-dimethylaminobutyryloxy)-2-methyl-N-2-pyridyl-2H-thieno[2,3-e][1,2]-thiazine-3-carboxamido-1,1-dioxide hydrochloride

6-chloro-4-(N,N-dimethylaminobutyryloxy)-2-methyl-N-2-pyridyl-2H-thieno[2,3-e][1,2]-thiazine-3-carboxamido-1,1-dioxide hydrochloride

Conditions
ConditionsYield
Stage #1: lornoxicam; N,N-dimethyl-γ-aminobutyric acid chloride hydrochloride With sodium hydrogencarbonate In water; acetone at 20℃; for 3h;
Stage #2: With hydrogenchloride
80.5%
lornoxicam
70374-39-9

lornoxicam

di(n-butyl)tin oxide
818-08-6

di(n-butyl)tin oxide

[Sn(n-C4H9)2(lornoxicam)]

[Sn(n-C4H9)2(lornoxicam)]

Conditions
ConditionsYield
In benzene Sn compd. added to soln. of ligand, refluxed for 27 h; evapd. in vac., chilled, triturated with hexane, redissolved in Et2O (repeated twice), filtered, dried in vac. over silica gel, elem. anal.;66%
lornoxicam
70374-39-9

lornoxicam

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

6-chloro-2-methyl-4-palmitoyloxy-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

6-chloro-2-methyl-4-palmitoyloxy-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
With triethylamine In tetrachloromethane for 1.5h; Ambient temperature;45%
lornoxicam
70374-39-9

lornoxicam

(Z)-9-octadecenoyl chloride
112-77-6

(Z)-9-octadecenoyl chloride

6-chloro-2-methyl-4-oleoyloxy-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

6-chloro-2-methyl-4-oleoyloxy-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
With triethylamine In tetrachloromethane for 1.5h; Ambient temperature;40%
lornoxicam
70374-39-9

lornoxicam

n-decanoyl chloride
112-13-0

n-decanoyl chloride

6-chloro-4-decanoyloxy-2-methyl-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

6-chloro-4-decanoyloxy-2-methyl-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
With pyridine In tetrahydrofuran for 24h; Heating;35%
lornoxicam
70374-39-9

lornoxicam

phosgene
75-44-5

phosgene

C14H9Cl2N3O5S2

C14H9Cl2N3O5S2

Conditions
ConditionsYield
In N,N-dimethyl-formamide; toluene a) 5 deg C, 2 h, b) RT, 24 h;
lornoxicam
70374-39-9

lornoxicam

2-chloro-1,3-(dipalmitoyloxy)propane
169471-41-4

2-chloro-1,3-(dipalmitoyloxy)propane

6-chloro-2-methyl-4-<2-(1,3-dipalmitoyloxy)propyloxy>-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

6-chloro-2-methyl-4-<2-(1,3-dipalmitoyloxy)propyloxy>-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
With sodium hydride 1.) THF, 2.) THF, RT, 6 h; Yield given. Multistep reaction;
lornoxicam
70374-39-9

lornoxicam

C36H67ClO6

C36H67ClO6

4-<<2-(1,3-dipalmitoyloxy)propyl>carbonyloxy>-6-chloro-2-methyl-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

4-<<2-(1,3-dipalmitoyloxy)propyl>carbonyloxy>-6-chloro-2-methyl-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
In chloroform; toluene at 60℃; for 2h; Yield given;
lornoxicam
70374-39-9

lornoxicam

4-<<2-(1,3-dipalmitoyloxy)propyl>carbonyloxy>-6-chloro-2-methyl-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

4-<<2-(1,3-dipalmitoyloxy)propyl>carbonyloxy>-6-chloro-2-methyl-N-2-pyridinyl-2H-thieno<2,3-e>-1,2-thiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethylformamide; toluene / a) 5 deg C, 2 h, b) RT, 24 h
2: dimethylformamide / 6 h / 50 °C
View Scheme
lornoxicam
70374-39-9

lornoxicam

1-Chloroethyl ethyl carbonate
50893-36-2

1-Chloroethyl ethyl carbonate

6-chloro-4-(1-(ethoxycarbonyloxy)ethoxy)-2-methyl-N-(pyridin-2-yl)-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide

6-chloro-4-(1-(ethoxycarbonyloxy)ethoxy)-2-methyl-N-(pyridin-2-yl)-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
With sodium iodide; potassium carbonate In dichloromethane; water; acetone
lornoxicam
70374-39-9

lornoxicam

methanol
67-56-1

methanol

A

methyl 5-chloro-2-thiophenecarboxylate
35475-03-7

methyl 5-chloro-2-thiophenecarboxylate

B

N-methyl-N'-(pyridin-2-yl)oxalamide

N-methyl-N'-(pyridin-2-yl)oxalamide

C

N-methyl-N'-(pyridin-2-ylcarbamoyl)methanethioamide

N-methyl-N'-(pyridin-2-ylcarbamoyl)methanethioamide

D

5-chloro-N-methyl-3-oxothieno[2,3-d]-1,2-thiazole-1,1-dioxide

5-chloro-N-methyl-3-oxothieno[2,3-d]-1,2-thiazole-1,1-dioxide

E

methyl (pyridin-2-ylcarbamoyl)formate
54166-60-8

methyl (pyridin-2-ylcarbamoyl)formate

Conditions
ConditionsYield
for 7h; Irradiation;
lornoxicam
70374-39-9

lornoxicam

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

C42H70O35*C13H10ClN3O4S2

C42H70O35*C13H10ClN3O4S2

Conditions
ConditionsYield
In ethanol; water for 24h; pH=2.5; pH-value;
lornoxicam
70374-39-9

lornoxicam

cyclomaltooctaose
17465-86-0

cyclomaltooctaose

C48H80O40*C13H10ClN3O4S2

C48H80O40*C13H10ClN3O4S2

Conditions
ConditionsYield
In ethanol; water for 24h; pH=2.5; pH-value;

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