70374-39-9 Usage
Description
Different sources of media describe the Description of 70374-39-9 differently. You can refer to the following data:
1. Lornoxicam (Trade name: “Xefo”) belongs to a non-steroidal anti-inflammatory drug. As a kind of oxicam class drug, it has analgesic, anti-inflammatory and antipyretic properties. It can be used for the treatment of various type of acute mild to moderate pain which results from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and rheumatic diseases. Lornoxicam is capable of potently inhibiting the prostaglandin biosynthesis process, making it have highly pronounced efficacy. The exact mechanism of Lornoxicam is not exactly understood. However, it is indicated that Lornoxicam can inhibit the prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2, leading to reduction of inflammation, pain, fever, and swelling.
2. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 (TXB2; ) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in HEL human erythroleukemic cells (IC50 = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α (PGF1α; ) from arachidonic acid in Mono-Mac-6 cells (IC50 = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 μM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.
3. Lornoxicam is a nonselective NSAID for oral and intravenous administration. It has been available for human use since two decades and there is a growing body of evidence supporting its efficacy and tolerability for management of acute pain.Xefo, a member of the oxicam family of nonsteroidal antiinflammatory agents, was launched in Denmark for mild to moderate pain and inflammation. A seven step synthesis, beginning with 2,5-dichlorothiophene, provides access to this compound. It inhibits prostaglandin synthesis at the level of cyclooxygenase (Cox1 :Cox2 = 0.6) but does not inhibit 5-lipoxygenase. Xefo did not increase serum levels of pepsinogen I (an indicator of gastric mucosal status) and readily penetrates perivascular interstitial spaces including synovial fluid. It is as effective as morphine, meperidine and tramadol in relieving post operative pain and as efficient as other NSAlDs in relieving the symptoms of osteoarthritis and rheumatoid arthritis. It is 100 times more potent than Tenoxicam in inhibiting PGD2 and more active than indomethacin (6x) or piroxicam (10x) in preventing arachadonic acid influenced lethality in mice. Xefo has inhibitor effects on spinal nocicceptive processing presumably via release of endogenous opiods and evidence suggests it is good for migraine.
References
https://www.drugbank.ca/drugs/DB06725
https://en.wikipedia.org/wiki/Lornoxicam
Chemical Properties
Crystalline Solid
Originator
Nycomed Amersham (Norway)
Uses
Different sources of media describe the Uses of 70374-39-9 differently. You can refer to the following data:
1. Lornoxicam belongs to the oxicam class. It has anti-inflammatory and antipyretic properties. Lornoxicam prevents the synthesis of prostaglandin (PG) by inhibiting cyclo-oxygenase. It is used to relieve various types of symptoms associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.Lornoxicam is approved for use in Japan.Lornoxicam has been used as a drug in melanin binding study with cassette dosing and rapid equilibrium dialysis inserts. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug.
2. For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.
3. Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic
Definition
ChEBI: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for th
treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.
Indications
Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) that is used as a painkiller (analgesic). A high level of pain relief is experienced by about 45% of those with moderate to severe postoperative dental pain after a single dose of lornoxicam 8 mg, compared to about 10% with placebo. This is comparable to the proportion experiencing the same level of pain relief with ibuprofen 200 to 400 mg. Adverse events were generally mild and did not differ from placebo in these singe dose studies. There were insufficient data to assess duration of action, but it is likely to be similar to ibuprofen 200 mg.
Brand name
Xefo
in vitro
studies on intact human cells showed that lornoxicam intensively inhibit cox-1 and cox-2 with the lowest ic50 among a large panel of nsaids tested. similar findings were obtained in the whole blood for cox-1/-2. in addition lornoxicam suppressed no formation in a dose-dependently manner with an ic50 of 65 μm. [2]
in vivo
in vivo studies found that lornoxicam was as effective as comparative nsaids and that 8 mg lornoxicam was more effective than 10 mg morphine as a pain-reliever after oral surgery. orally administration of lornoxicam at 16-24 mg daily was more effective than tramadol at 300 mg daily in pain-alleviating after knee surgery. compared to naproxen, lornoxicam showed higher therapeutic potency and lower gastrointestinal toxicity. this was probably due to the short half-life of lornoxicam as compared to the other oxicams. [3]
IC 50
a potent cox-1 and cox-2 inhibitor with ic50 values of 5 nm and 8 nm, respectively.
references
[1]balfour ja, fitton a and barradell lb. lornoxicam, a review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions. drugs. 1996 apr; 51(4): 639-57.[2]berg j, fellier h, christoph t, grarup j and stimmeder d. the analgesic nsaid lornoxicam inhibits cyclooxygenase (cox)-1/-2, inducible nitric oxide synthase (inos), and the formation of interleukin (il)-6 in vitro. inflamm res. 1999 jul; 48(7): 369-79.[3]radhofer-welte s and rabasseda x. lornoxicam, a new potent nsaid with an improved tolerability profile. drugs today (barc). 2000 jan; 36(1): 55-76.[4]sharma a, pingle a, and baliga vp. lornoxicam efficacy in acute pain (leap) trial. j indian med assoc. 2008 dec; 106(12): 811-3.
Check Digit Verification of cas no
The CAS Registry Mumber 70374-39-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,3,7 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 70374-39:
(7*7)+(6*0)+(5*3)+(4*7)+(3*4)+(2*3)+(1*9)=119
119 % 10 = 9
So 70374-39-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
70374-39-9Relevant articles and documents
Synthesis method of high-purity lornoxicam
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Paragraph 0038-0062, (2021/10/11)
The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of high-purity lornoxicam. The method comprises the following steps: by taking 6-chloro-4-hydroxy-2-methyl-2-H-thieno [2, 3-e]-1, 2-thiazine carboxylic acid methyl ester-1, 1-dioxide and 2-aminopyridine as raw materials and xylene as a solvent, carrying out distillation reaction, condensing mixed gas obtained by the distillation reaction to obtain condensate, adsorbing methanol in the condensate by adopting a solid acid catalyst, and recycling the adsorbed condensate. According to the invention, the methanol generated by the reaction is distilled out so as to promote the reaction to proceed forwards, and then the methanol is absorbed under the catalysis of H2SO4/MxOy superacid solid acid, so that the xylene returned to the reaction system does not contain methanol, and the coking of the reaction is reduced so as to improve the product quality and yield; and the purity of the prepared lornoxicam is high and can reach 99.9% or above, the solvent amount is reduced, and the method is suitable for industrial production.
