7038-67-7

Basic information

• Product Name: 2-(PIPERIDIN-1-YL)-4,6-DICHLOROPYRIMIDINE
• Synonyms: 2-(PIPERIDIN-1-YL)-4,6-DICHLOROPYRIMIDINE;4,6-dichloro-2-(piperidin-1-yl)pyriMidine
• CAS NO: 7038-67-7
• Molecular Formula: C9H11Cl2N3
• Molecular Weight: 232.11
• Mol File: 7038-67-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 369.2°Cat760mmHg
• Flash Point: 177.1°C
• Appearance: /
• Density: 1.349g/cm³
• Vapor Pressure: 1.21E-05mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(PIPERIDIN-1-YL)-4,6-DICHLOROPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PIPERIDIN-1-YL)-4,6-DICHLOROPYRIMIDINE(7038-67-7)
• EPA Substance Registry System: 2-(PIPERIDIN-1-YL)-4,6-DICHLOROPYRIMIDINE(7038-67-7)

Safety Data

• Hazardous Substances Data: 7038-67-7(Hazardous Substances Data)

Usage

General Description

2-(Piperidin-1-yl)-4,6-dichloropyrimidine is a chemical compound with a molecular formula C9H9Cl2N3. It is a pyrimidine derivative with a piperidine moiety attached to the 2 position of the pyrimidine ring. 2-(PIPERIDIN-1-YL)-4,6-DICHLOROPYRIMIDINE is known for its use in medicinal chemistry, particularly in the development of pharmaceuticals. It has been studied for its potential as an antiviral and antitumor agent, with research focusing on its biological activity and structure-activity relationships. Furthermore, 2-(Piperidin-1-yl)-4,6-dichloropyrimidine has also been investigated for its potential as an insecticide and herbicide. Overall, this chemical compound is of interest in various fields due to its diverse potential applications ranging from medicine to agriculture.

InChI:InChI=1/C9H11Cl2N3/c10-7-6-8(11)13-9(12-7)14-4-2-1-3-5-14/h6H,1-5H2

Upstream product

• 110-89-4 piperidine 
• 4489-34-3 4,6-dichloro-2-(methylsulfonyl)pyrimidine 
• 3764-01-0 2,4,6-trichloropyrimidine 

Relevant articles and documents

Chemoselective reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and related electrophiles with amines

Chemoselective SNAr reactions of 4,6-dichloro-2-(methylsulfonyl) pyrimidine and several related electrophiles with amines and their derivatives are described. In the presence of weak bases anilines and secondary aliphatic amines selectively displace the chloride group. Deprotonated anilines and their carbonyl derivatives displace the sulfone group. Sterically and electronically unbiased primary aliphatic amines selectively displace the sulfone group in 4,6-dichloro-2-(methylsulfonyl)pyrimidine; however, their reactions with other electrophiles generally are less selective. Steric-driven selectivity explanation was proposed. Georg Thieme Verlag Stuttgart. New York.

Novel antiallergic agents. Part I: Synthesis and pharmacology of pyrimidine amide derivatives

We have synthesized many pyrimidine amide derivatives. Novel pyrimidine bis-glycolic amide derivatives showed moderate inhibition in the rat passive cutaneous anaphylaxis (PCA) assay by oral administration. Among these compounds, 2,4-bis(methoxyacetylamino)-6-piperidinopyrirnidine (2i) exhibited significant inhibition. However the compound (2i) did not inhibit antigen-induced histamine or SRS-A release from lung fragments of the guinea-pig at less than 10-4 M. Derivatives of 2i have also notable or moderate activity in the rat PCA assay. Compound 2h which has no oxygen atom at the α-position of the amide carbonyl group and, compound 17 which has no amide carbonyl group, showed no inhibition in the rat PCA assay. We supposed that both the amide carbonyl group and the oxygen atom at α-position of the amide carbonyl group play an important role in inhibiting the rat PCA reaction. These pyrimidine bis-glycolic amide derivatives have a novel structure and unique activity which suggests they may be potentially useful in the treatment of allergic diseases. Copyright (C) 1998 Elsevier Science Ltd.