70390-92-0

Usage

Chemical Class

The compound belongs to the class of organic compounds known as indoles.

Molecular Weight

The molecular weight of the compound is 568.81 g/mol.

Sulfonylated Indole Derivative

The compound contains a sulfonyl group attached to the indole ring.

Common Uses

The compound is commonly used in the research and development of pharmaceuticals, agrochemicals, and other organic synthesis applications.

2,4,6-Trimethylphenyl Group

The 2,4,6-tris(1-methylethyl)phenyl group attached to the sulfonyl group contributes to the compound's physical and chemical properties, making it useful for various industrial and laboratory processes.

Downstream Products

• 1242733-98-7 1-(2',4',6'-triisopropylphenylsulfonyl)-2-(phenylthio)-1H-indole 
• 1242733-99-8 1-(2',4',6'-triisopropylphenylsulfonyl)-2-(phenylsulfonyl)-1H-indole 
• 1242733-95-4 3-n-butyl-2-(phenylsulfonyl)-1H-indole 

Relevant academic research and scientific papers

4-(1-(SULFONYL)-1H-INDOL-2-YL)-4-(HYDROXY)-CYCLOHEXA-2,5-DIENONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC AGENTS

This invention pertains to certain 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds, and analogs thereof, including compounds of the following formula, which are, inter alia, antiproliferative agents, anticancer agents, and/or thioredoxin/thioredoxin reductase inhibitors: formula (I) wherein: Ar is a 1-(sulfonyl)-1H-indol-2-yl group; the bond marked α is independently: (a) a single bond; or: (b) a double bond; the bond marked β is independently: (a) a single bond; or: (b) a double bond; the group -ORO is independently: (a) -OH; (b) an ether group (e.g., -OMe); or: (c) an acyloxy (i.e., reverse ester) group (e.g., -OC(=O)Me); each of R2, R3, R5, and R6, is independently a ring substituent and is: (a) H; (b) a monovalent monodentate substituent; or: (c) a ring substituent which, together with an adjacent ring substituent, and together with the ring atoms to which these ring substituents are attached, form a fused ring; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), and/or conditions mediated by thioredoxin/thioredoxin reductase.