70390-97-5

Upstream product

• 33575-83-6 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole 
• 613-94-5 benzoic acid hydrazide 
• 4046-03-1 2-methyl-5-phenyl-[1,3,4]oxadiazole 
• 90507-19-0 2-<(hydroxyimino)methyl>-5-phenyl-1,3,4-oxadiazole 

Downstream Products

• 68496-63-9 5-phenyl-1,3,4-oxadiazole-2-carbonitrile 
• 90507-27-0 5-phenyl-1,3,4-oxadiazole-2-thiohydroximic acid 2-(diethylamino)ethyl S-ester 
• 70391-03-6 N-hydroxy-5-phenyl-[1,3,4]oxadiazole-2-carboximidoyl azide 

Relevant academic research and scientific papers

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Nonquaternary cholinesterase reactivators. II. α-Heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro

We prepared six pairs of α-heteroaromatic aldoximes, RC(=NOH)H, and thiohydroximates, RC(=NOH)S(CH2)2N(C2H5)2, where R represents various oxadiazole and thiadiazole rings. Each compound was characteri