70391-06-9Relevant articles and documents
NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
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Page/Page column 50, (2008/12/08)
Heteroaromatic compounds of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein W is a substituted heteroaryl, X and Y are each independently a bond, -O-, -S-, -S(O)-, -S(O)2-, -NR6-, -C(O)-, -C(CH3)(OH)- or -C(CH3)=CH-, u is an integer from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis, obesity, Type 2 diabetes, insulin resistance, hyperglycemia, Metabolic Syndrome, neurological disease, cancer, and liver steatosis
Synthesis of 1,3,4-thiadiazole oligomers
Le, Van-Duc,Rees, Charles W.,Sivadasan, Sivaprasad
, p. 1543 - 1547 (2007/10/03)
A range of hydrazono chlorides 8, readily prepared from 5-substituted tetrazoles 7 and Appel salt 1, are rapidly converted by triphenylphosphine into 5-cyano-1,3,4-thiadiazoles 9 in high yield. These cyanides are converted by azide into the corresponding tetrazoles 10 which with Appel salt give the hydrazono chlorides 11 which are similarly converted by triphenylphosphine into the bi-1,3,4-thiadiazolyls 12a,c,g, all in high yield. Repetition of the 3-step sequence (12 → 13 → 14 → 15) gives the ter-1,3,4-thiadiazolyls 15a,g.
1,3,4-Thiadiazole-2-carboxylic acid derivatives, process for making the same and fungicidal and nematocidal compositions containing same
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, (2008/06/13)
1,3,4-thiadiazole-2-carboxylic acid derivatives of the formula STR1 wherein R is C1 -C6 -alkyl, C2 -C6 -alkenyl, C2 -C6 -alkinyl or C3 -C6 -cycloalkyl, R1 i
