70396-17-7Relevant academic research and scientific papers
Synthesis of Eight-Membered Nitrogen Heterocycles via a Heterogeneous PtI2-Catalyzed Cascade Cycloaddition Reaction of δ-Aminoalkynes with Electron-Deficient Alkynes
Li, Xinhong,Wang, Songmeng,Wang, Hongkai,Wang, Weilin,Liu, Lingyan,Chang, Weixing,Li, Jing
, p. 1525 - 1531 (2020/03/23)
A novel heterogeneous PtI2-catalyzed cascade reaction of δ-aminoalkynes was developed for the synthesis of various eight-membered nitrogen heterocycles in excellent yields. The reaction proceeds via a hydration of δ-aminoalkynes and subsequent intramolecular cyclization and intermolecular addition as well as ring-expansion cascade reaction with another electron-deficient alkynes. This method has the advantages of simple operation and mild reaction conditions. And the simple PtI2 with no any supports could be readily recycled through simple centrifugation without substantial loss of activity in 1,2-dichloroethane (DCE). The recyclability of PtI2 may be ascribed to its insolubility in DCE. The reaction constitutes a formal [6+2]-cycloaddition. (Figure presented.).
Selectivity enhancement of epoxide hydrolase catalyzed resolution of 2,2-disubstituted oxiranes by substrate modification
Osprian, Ingrid,Stampfer, Wolfgang,Faber, Kurt
, p. 3779 - 3785 (2007/10/03)
A series of (+)-2,2-disubstituted oxiranes bearing an alkene or alkyne functional group were resolved by bacterial epoxide hydrolases with excellent selectivities. The presence of a carbon-carbon double or triple bond furnished a highly flexible system fo
Oxidative Cyclization of δ,ε- and ε,ζ-Unsaturated Enol Silyl Ethers and Unsaturated Siloxycyclopropanes
Snider, Barry B.,Kwon, Taesoo
, p. 2399 - 2410 (2007/10/02)
Oxidative cyclization of δ,ε- and ε,ζ-unsaturated enol silyl ethers 4a and 4b with cupric triflate and cuprous oxide or ceric ammonium nitrate and sodium bicarbonate in acetonitrile provides the tricyclic ketones 5a and 5b stereoselectively.These cyclizat
