704-22-3Relevant academic research and scientific papers
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases
Xu,Maga,Focher,Smith,Spadari,Gambino,Wright
, p. 49 - 57 (2007/10/02)
Two series of selective inhibitors of herpes simplex virus types 1 and 2 (HSV1,2) thymidine kinases (TK) have been developed as potential treatment of recurrent virus infections. Among compounds related to the potent base analog N2-[m-(trifluor
4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide
Mrozik,Bochis,Eskola,Matzuk,Waksmunski,Olen,Schwartzkopf Jr.,Grodski,Linn,Lusi,Wu,Shunk,Peterson,Milkowski,Hoff,Kulsa,Ostlind,Campbell,Riek,Harmon
, p. 1225 - 1227 (2007/10/06)
The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3- benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.
