70432-82-5

Upstream product

• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 140-29-4 phenylacetonitrile 
• 70432-80-3 3-(2.3.-Dimethoxyphenyl)-2-phenylacrylnitril 

Downstream Products

• 70432-90-5 γ-(2.3.-Dimethoxyphenyl)-β-phenylbuttersaeure 
• 70432-91-6 5,6-dimethoxy-3-phenyl-1,2,3,4-tetrahydro-1-naphthalenone 
• 70432-83-6 4,5-Dimethoxy-2-phenyl-1-indanon 
• 70432-89-2 γ-(2,3-Dimethoxyphenyl)-β-phenylpropyl-methansulfonat 
• 70432-86-9 N-(4,5-Dimethoxy-2-phenyl-3H-inden-1-yl)-formamide 

Relevant academic research and scientific papers

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))