70441-27-9Relevant academic research and scientific papers
Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds
Fisher, David J.,Burnett, G. Leslie,Velasco, Rocío,Read De Alaniz, Javier
, p. 11614 - 11617 (2015)
The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.
