70450-87-2

Upstream product

• 123-54-6 acetylacetone 
• 667-27-6 Ethyl bromodifluoroacetate 
• 62-53-3 aniline 
• 1035459-52-9 3-[3,4-dimethyl-1-(toluene-4-sulfonyl)-imidazolidin-2-yl]-pentane-2,4-dione 
• 33884-41-2 ethoxylideneacetylacetone 
• 60-29-7 diethyl ether 
• 864131-95-3 N,N'-diphenylformamidine 
• 14024-58-9 manganous acetylacetonate 
• 14024-18-1 iron(III)-acetylacetonate 

Relevant academic research and scientific papers

Catalytic synthesis method of 1,3-dicarbonyl compounds

The invention discloses a catalytic synthesis method of 1,3-dicarbonyl compounds. According to the catalytic synthesis method, with the participation of sodium carbonate, aniline compounds and ethyl bromide difluoroacetate are subjected to defluorination

Synthesis of β-Aminoenones via Cross-Coupling of In-Situ-Generated Isocyanides with 1,3-Dicarbonyl Compounds

An efficient and practical strategy for the synthesis of β-aminoenones from a three-component reaction was developed. Ethyl bromodifluoroacetate serves as a C1 source in this strategy, forming isocyanides in situ with primary amines. This reaction represents the first example of utilization of readily available starting materials to generate isocyanides in situ and sequentially fully converted to β-aminoenones, avoiding the generation of byproduct imines and overinsertion products. The mechanism study suggested that this method involves activation of two C(sp3)-F bonds and the formation of isocyanides, which might nourish both isocyanide chemistry and fluorine chemistry.

Synthesis of functionalized β-enamino compounds by carbon-fragment transfer reaction of C(2)-substituted imidazolidines with amines

The substituted imidazolidines (2, 3, 5) and a ring-opening product, N,N,N'-trisubstituted 2-methyl-ethylenediamines (4), derived from addition of the carbon anions to 1-tosyl-3,4-dimethylimidazolinium iodide (1), were utilized to transfer substituted one-carbon units to various amines to yield a series of functionalized β-enamino compounds.

PHARMACEUTICAL COMPOSITION COMPRISING 2-PYRIDONE DERIVATIVE AS ACTIVE INGREDIENT

Disclosed is a 2-pyridone derivative having an inhibitory effect on cell adhesion and is useful for the prevention and treatment of a morbid condition associated with leukocyte migration, such as an inflammation. A 2-pyridone derivative represented by the formula (I): (I) wherein R1 represents a phenyl or pyridyl group or the like; R2 represents a phenyl group or the like; R3 represents a lower alkyl group or the like; R4 represents a lower alkyl group or the like; R5 represents a lower alkyl group or the like; and R6 represents a lower alkyl group or the like.

Solvent-free synthesis of quinolone derivatives

Quinolones can be prepared in a three step procedure from triethylorthoformate and activated methylene derivatives leading to alkoxymethylenemalonates followed by reaction with aromatic amines and finally a cyclization. All the reactions were carried out under solvent-free conditions possibly under microwave activation with benefits for the first step.

NMR of enaminones: Part 4 - 17O NMR study of 2,2-diacylenamines

Natural abundance 17O NMR spectra of 41 2,2-diacylenamines (enamino diketones and enamino diesters), recorded in acetonitrile solution, are reported. Tertiary enamino diketones show only one 17O signal; primary and secondary derivati