70451-27-3Relevant academic research and scientific papers
Potassium Acetate-Catalyzed Double Decarboxylative Transannulation to Access Highly Functionalized Pyrroles
Jia, Chunman,Li, Jun-Kuan,Ma, Jun-An,Tian, Yu-Chen,Xue, Xiao-Song,Zhang, Fa-Guang,Zhou, Biying
, p. 9585 - 9590 (2020)
The development of new synthetic strategies for the efficient construction of versatile pyrrole pharmacores, especially in an operationally simple and environmentally benign fashion, still remains a momentous yet challenging goal. Here, we report a KOAc-catalyzed double decarboxylative transannulation between readily accessible oxazolones and isoxazolidinediones. This transformation represents a new way for skeletal remodeling by utilizing CO2 moiety as traceless activating and directing groups in both reaction partners. The synthetic value is evidenced by the rapid preparation of a broad spectrum of highly functionalized 3-carbamoyl-4-aryl pyrroles in good to excellent yields with exclusive regio-control, including the important Atorvastatin core.
Polysubstituted pyrrole compound as well as quick preparation method and application thereof (by machine translation)
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Paragraph 0020-0022; 0077-0079, (2020/07/15)
The invention provides a novel method for rapidly preparing polysubstituted pyrrole compounds (I), wherein Ar is used in the invention. 1 And Ar2 Aromatic groups, R1 And R2 The same or different fatty alkane groups and aromatic groups may be used. The method has the advantages of non-metal catalysis, higher conversion rate, excellent regional specificity and wide substrate universality and the like, and can effectively synthesize a fluxapyrone pyrrole parent nucleus structure under mild conditions, and a novel method is provided for synthesis. , The method provides a new way for constructing a compound containing a polysubstituted pyrrole skeleton structure. (by machine translation)
