70452-29-8Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds
Zhou, Andong,Yan, Lei,Lai, Fangfang,Chen, Xiaoguang,Goto, Masuo,Lee, Kuo-Hsiung,Xiao, Zhiyan
, p. 3326 - 3331 (2017)
The indolin-2-one core is a privileged structure for antitumor agents, especially kinase inhibitors. Twenty-three novel indolin-2-ones were designed by molecular dissection of the anticancer drug indirubin. Seventeen of them exhibited significant inhibition against the tested cell lines, and two of them (1c and 1h) showed IC50 values at the submicromolar level against HCT-116 cells. Compounds 1c and 2c were also potent inhibitors of the triple-negative breast cancer (TNBC) cell line MDA-MB-231. Flow cytometry was utilized to explore the antitumor mechanism of 1c and 2c with MDA-MB-231 cells, and distinct effects were observed on 2c. Furthermore, immunocytochemical examination of 1c suggested a destabilization of microtubules, which was significantly different from the effect of IM, an indirubin derivative.
Synthesis and bioactivity assessment of novel spiro pyrazole-oxindole congeners exhibiting potent and selective in vitro anticancer effects
Abdelhamid, Sayeda A.,Abo-Salem, Heba M.,Aboul-Soud, Mourad A. M.,Al-Sheikh, Yazeed A.,Ebied, Manal S.,El-Sawy, Eslam R.,Elawady, Mohamed E.,Nassrallah, Amr,Soliman, Ahmed A. F.
, (2020/03/17)
The present work aims to design and synthesize novel series of spiro pyrazole-3,3'-oxindoles analogues and investigate their bioactivity as antioxidant and antimicrobial agents, as well as antiproliferative potency against selected human cancerous cell li
