70453-86-0

Upstream product

• 71599-78-5 3-oxo-3-phenyl-propionic acid o-toluidide 
• 95-53-4 o-toluidine 

Downstream Products

• 133131-95-0 2-bromo-8-methyl-4-phenyl-quinoline 
• 26119-60-8 8,8'-dimethyl-4,4'-diphenyl-[2,2']biquinolyl 
• 113431-45-1 2-chloro-8-methyl-4-phenylquinoline 
• 113431-46-2 4-phenyl-8-methylquinoline 
• 113431-47-3 4-phenylquinoline-8-carboxylic acid 
• 113431-36-0 4-Phenyl-quinoline-8-carboxylic acid (2-dimethylamino-ethyl)-amide; hydrochloride 
• 126274-66-6 Acetic acid 4-phenyl-quinolin-8-ylmethyl ester 
• 126274-74-6 (1-Ethyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-8-yl)-methanol 
• 112662-56-3 8-(1H-Benzoimidazol-2-ylsulfanylmethyl)-1-ethyl-4-phenyl-1,2,3,4-tetrahydro-quinoline 
• 112645-05-3 8-(1H-Benzoimidazole-2-sulfinylmethyl)-1-ethyl-4-phenyl-1,2,3,4-tetrahydro-quinoline 

Relevant academic research and scientific papers

A Facile Synthesis of 5-Phenyl-Dibenzo[b, g][1,8]Napthyridines

The Vilsmeier Haack heterocyclization of 2-aryl amino-4-phenyl quinolines quinoline yielded the hitherto unknown 5-phenyl-dibenzo[b,g][1,8]naphthyridines in quantitative yield. The synthesis of aryl amines was achieved by the action of anilines on 2-chloro-4-phenyl quinoline, which in turn was sourced through the combes reaction of benzoyl acetanilides.

Synthesis and anticonvulsant activity of 5-phenyl-[1,2,4]-triazolo[4,3-a] quinolines

A series of novel 5-phenyl-[1,2,4]-triazolo[4,3-a]quinoline derivatives was synthesized by the cyclization of 2-chloro-4-phenyl-1,2-dihydronaphthalene with formohydrazide. The starting material 2-chloro-4-phenyl-1,2-dihydronaphthalene was synthesized from ethyl-3-oxo-3-phenylpropanoate and substituted aniline. Their anticonvulsant activities were evaluated by the maximal electroshock (MES) test and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox). The maximal electroshock test showed that 7-hexyloxy-5-phenyl-[1,2,4]- triazolo[4,3-a]quinoline 4f was found to be the most potent compound with an ED50 value of 6.5 mg/kg and a protective index (PI = ED 50/TD50) value of 35.1, which was much higher than the PI of the reference drug phenytoin.

Pyridine and related aza heterocycle derivatives as cardiovascular agents

Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: wherein R1 or R3 is a moiety of the formula: wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals.