70498-40-7

Upstream product

• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 75-31-0 isopropylamine 
• 64-17-5 ethanol 
• 162101-10-2 N-(4-chloro-phenylthiocarbamoyl)-S-methyl-isothiourea 

Downstream Products

• 130256-04-1 4-(4-Chloro-phenyl)-2-isopropyl-3-thioxo-[1,2,4]thiadiazolidin-5-one 
• 130255-92-4 4-(4-Chloro-phenyl)-5-[(Z)-isopropylimino]-[1,2,4]dithiazolidin-3-one 

Relevant academic research and scientific papers

Ph3P/I2-mediated synthesis of N,N′,N″-substituted guanidines and 2-iminoimidazolin-4-ones from aryl isothiocyanates

A convenient one-pot procedure for the synthesis of acyclic and cyclic guanidines mediated by the Ph3P/I2 system is described. Sequential condensation of aryl isothiocyanates with amines followed by dehydrosulfurization and guanylation could lead to both symmetric and unsymmetric N,N′,N″-substituted derivatives. Through a tandem guanylation-cyclization, a series of 2-iminoimidazolin-4-ones could also be prepared in good yields from the reaction of aryl isothiocyanates with amino acid methyl esters.