70504-01-7 Usage
Uses
Used in Membrane Research:
PRODAN is used as a fluorescent probe for studying the physical state of phospholipids in membranes. Its sensitivity to the state of the surrounding phospholipids allows researchers to gain insights into membrane dynamics and interactions.
Used in Fluorescence Spectroscopy:
PRODAN is widely used as a fluorescent molecule probe in fluorescence spectroscopy due to its significant Stokes shift in polar solvents. This property makes it an ideal candidate for detecting changes in the local environment of the probe, which can be useful in various applications, such as studying protein-ligand interactions and monitoring changes in membrane fluidity.
Check Digit Verification of cas no
The CAS Registry Mumber 70504-01-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,5,0 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70504-01:
(7*7)+(6*0)+(5*5)+(4*0)+(3*4)+(2*0)+(1*1)=87
87 % 10 = 7
So 70504-01-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H17NO/c1-4-15(17)13-6-5-12-10-14(16(2)3)8-7-11(12)9-13/h5-10H,4H2,1-3H3
70504-01-7Relevant academic research and scientific papers
A Fluorescent Kinase Inhibitor that Exhibits Diagnostic Changes in Emission upon Binding
Fleming, Cassandra L.,Sandoz, Patrick A.,Inghardt, Tord,?nfelt, Bj?rn,Gr?tli, Morten,Andréasson, Joakim
supporting information, p. 15000 - 15004 (2019/09/17)
The development of a fluorescent LCK inhibitor that exhibits favourable solvatochromic properties upon binding the kinase is described. Fluorescent properties were realised through the inclusion of a prodan-derived fluorophore into the pharmacophore of an ATP-competitive kinase inhibitor. Fluorescence titration experiments demonstrate the solvatochromic properties of the inhibitor, in which dramatic increase in emission intensity and hypsochromic shift in emission maxima are clearly observed upon binding LCK. Microscopy experiments in cellular contexts together with flow cytometry show that the fluorescence intensity of the inhibitor correlates with the LCK concentration. Furthermore, multiphoton microscopy experiments demonstrate both the rapid cellular uptake of the inhibitor and that the two-photon cross section of the inhibitor is amenable for excitation at 700 nm.
