705060-10-2Relevant academic research and scientific papers
Inhibitors of ADP-Ribosylating Bacterial Toxins Based on Oxacarbenium Ion Character at Their Transition States
Zhou, Guo-Chun,Parikh, Sapan L.,Tyler, Peter C.,Evans, Gary B.,Furneaux, Richard H.,Zubkova, Olga V.,Benjes, Paul A.,Schramm, Vern L.
, p. 5690 - 5698 (2004)
The bacterial exotoxins, cholera toxin (CT), pertussis toxin (PT), and diphtheria toxin (DT), interfere with specific host proteins to cause tissue damage for their respective infections. The common toxic mechanism for these agents is mono-ADP-ribosylatio
