70523-24-9

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Bis(benzyloxy)pyrimidine-5-boronic acid is used as a key reactant in the design and synthesis of acyclic fleximer nucleoside analogues. These analogues are of significant interest in medicinal chemistry due to their potential as antiviral and anticancer agents. The boronic acid functionality in 2,4-BIS(BENZYLOXY)PYRIMIDINE-5-BORONIC ACID allows for the formation of stable covalent bonds with biological targets, such as enzymes or receptors, thereby modulating their activity and contributing to the therapeutic effects of the resulting nucleoside analogues.

InChI:InChI=1/C18H17BN2O4/c22-19(23)16-11-20-18(25-13-15-9-5-2-6-10-15)21-17(16)24-12-14-7-3-1-4-8-14/h1-11,22-23H,12-13H2

Upstream product

• 100-51-6 benzyl alcohol 
• 41244-53-5 5-bromo-2,4-bis(benzyloxy)pyrimidine 

Downstream Products

• 848945-14-2 2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine 
• 477726-79-7 5-[3-(2-Amino-pyrimidin-4-yl)-4-hydroxy-phenyl]-1 H-pyrimidine-2.4-dione 
• 1418269-03-0 2,4-bis(benzyloxy)-5-1-[(3,5-di-O-benzyl-2-deoxy-β-D-ribofuranosyl)-1H-imidazol-4-yl]pyrimidine 

Relevant academic research and scientific papers

Synthesis of 5-fluorovinyl derivatives of pyrimidines via Suzuki-Miyaura coupling and their 1,3-dipolar cycloaddition reactions with nitrones

A simple two-step synthesis of a new class of fluorinated isoxazolidinyl derivatives of pyrimidine is described. The reactions proceed via the Suzuki-Miyaura coupling followed by highly regioselective 1,3-dipolar cycloaddition with nitrones. Removal of th

"Molecular chameleons". Design and synthesis of a second series of flexible nucleosides

(Chemical Equation Presented) The second series of flexible shape-modified nucleosides is introduced. The "fleximers" feature the purine ring systems split into their individual imidazole and pyrimidine components. This structural modification serves to introduce flexibility to the nucleoside while still retaining the elements essential for recognition. As a consequence, these structurally innovative nucleosides can more readily adapt to their environment and should find use as bioprobes for investigating enzyme-coenzyme binding sites as well as nucleic acid and protein interactions. Their design and synthesis is described.