70529-42-9Relevant academic research and scientific papers
Synthesis and Platelet Aggregation Inhibitory Activity of 4,5-Bis(aryl)-2-substituted-thiazoles
Rynbrandt, Ronald H.,Nishizawa, Edward E.,Balogoyen, Doris P.,Mendoza, A. Rene,Annis, Kathleen A.
, p. 1507 - 1510 (1981)
In our continuing effort to discover compounds which inhibit collagen-induced platelet aggregation, we have screened compounds in a mouse pulmonary thromboembolism screen.Methyl 4,5-bis(4-methoxyphenyl)-2-thiazoleacetate (3) was very active in the above screen.However, 3 was active for less than 5 min when given orally to guinea pigs.As a result, our synthetic goal was to prepare 2-substituted thiazoles with a much longer duration of activity.This paper describes the preparation of a number 4,5-bis(aryl)-2-substituted-thiazoles and their in vitro and ex vivo activity against collagen-induced platelet aggregation.It was determined that 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole (16) is the most promising compound.
