705292-65-5

Upstream product

• 690257-79-5 (4R)-3-[(3R)-3-(4-bromophenyl)butanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 690257-80-8 (4R)-3-[(2R,3S)-2-bromo-3-(4-bromophenyl)butanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 690257-78-4 (R)-3-(3-(4-bromophenyl)acryloyl)-4-phenyloxazolidin-2-one 
• 690257-82-0 (2R,3S)-2-azido-3-(4-bromophenyl)butanoic acid 
• 1200-07-3 trans-4-bromocinnamic acid 
• 690257-81-9 (4R)-3-[(2S,3S)-2-azido-3-(4-bromophenyl)butanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 853731-15-4 (2S,3S)-2-Azido-3-(4-bromo-phenyl)-1-((S)-3-fluoro-pyrrolidin-1-yl)-butan-1-one 

Downstream Products

• 870773-52-7 butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate 
• 870773-51-6 tert-butyl [(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-(4-oxocyclohexyl)propyl]carbamate 
• 870773-50-5 tert-butyl {(1S,2S)-1-{[(3S)-3-fluoropyrrolidin-1-yl]carbonyl}-2-[4-hydroxyphenyl]propyl}carbamate 
• 690257-93-3 (3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine 
• 690257-83-1 (3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-(4-bromophenyl)-1-oxobutanyl]-3-fluoropyrrolidine 

Relevant academic research and scientific papers

CYCLOHEXYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

anti-Substituted β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. These are among the most potent compounds reported to date lacking an electrophilic trap. The mo