70553-75-2Relevant articles and documents
Nodulisporic acid e biosynthesis:: In vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold
Van De Bittner, Kyle C.,Cameron, Rosannah C.,Bustamante, Leyla Y.,Bundela, Rudranuj,Kessans, Sarah A.,Vorster, Jan,Nicholson, Matthew J.,Parker, Emily J.
, p. 1160 - 1164 (2019/07/25)
Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas other related enzymes were not able to catalyse this conversion.