70555-53-2

Basic information

• Product Name: 5,7-DIMETHYLINDOLINE
• Synonyms: 5,7-DIMETHYLINDOLINE;AKOS BBV-003420;OTAVA-BB 1118832;2,3-dihydro-5,7-diMethyl-1H-Indole;5,7-Dimethyl-2,3-dihydro-1H-indole
• CAS NO: 70555-53-2
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Mol File: 70555-53-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,7-DIMETHYLINDOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DIMETHYLINDOLINE(70555-53-2)
• EPA Substance Registry System: 5,7-DIMETHYLINDOLINE(70555-53-2)

Safety Data

• Hazardous Substances Data: 70555-53-2(Hazardous Substances Data)

Upstream product

• 88106-98-3 β-(3,5-Dimethylphenyl)ethanesulfonyl chloride 
• 62343-67-3 β-(3,5-Dimethylphenyl)ethyl alcohol 
• 93427-11-3 β-(3,5-Dimethylphenyl)ethyl bromide 
• 54020-53-0 7-methyl-5-methyl-1H-indole 
• 70555-51-0 β-(3,5-Dimethylphenyl)ethanesulfonyl azide 

Relevant articles and documents

Bioavailable acyl-CoA : Cholesterol acyltransferase inhibitor with anti- peroxidative activity: Synthesis and biological activity of novel indolinyl amide and urea derivatives

We synthesized a series of indoline derivatives with an amide or urea moiety and examined their inhibitory effects on acyl-CoA : cholesterol acyltransferase (ACAT) activity, lipid-peroxidation and serum cholesterol levels in experimental animals. Among the derivatives synthesized, a series of N-(1-alkyl-4,6- dimethylindolin-7-yl)-2,2-dimethylpropanamides potently inhibited rabbit intestinal ACAT activity and lipid-peroxidation of rat brain homogenate. The effect on ACAT activity was related to the length of the alkyl chain at the 1-position of indoline. N-(4,b-Dimethyl-1-octylindolin-7- yl)-2,2-dimethylpropanamide hydrochloride (55) showed inhibitory effects on intestinal and hepatic ACAT activity slightly weaker than those of YM-750, and an inhibitory effect on low density lipoprotein (LDL)-peroxidation similar to that of probucol. Compound 55 also reduced serum cholesterol at 10 mg/kg/d in hyperlipidemic rats and 20 mg/kg/d in normolipidemic hamsters. The plasma concentration of 55 reached 716 ng/ml in dogs (10 mg/kg, p.o.), which is an effective concentration against hepatic ACAT activity and LDL- peroxidation. In conclusion, compound 55 is a novel bioavailable ACAT inhibitor with anti-peroxidative activity and is thus a promising anti- atherosclerotic and anti-hyperlipidemic drug. Indoline proved to be a useful pharmacophore for molecular design of new anti-peroxidative drugs.