70557-83-4Relevant academic research and scientific papers
Ir-catalyzed arylation, alkylation of quinones with boronic acids through C-C coupling
Wang, Dawei,Ge, Bingyang,Ju, Anqi,Zhou, Yucheng,Xu, Chongying,Ding, Yuqiang
, p. 30 - 33 (2015)
Ir-catalyzed arylation, alkylation of quinones with boronic acids was developed under room temperature. Both aryl and alkyl boronic acids are suitable for this transformation. This expands the application scope of the iridium catalyst. This is also an excellent proof that iridium catalysts can be used in the C-C coupling of quinones and naphthoquinones with alkyl boronic acids.
Synthesis of aryl substituted quinones as β-secretase inhibitors: Ligand-free direct arylation of quinones with aryl halides
Wang, Dawei,Ge, Bingyang,Yang, Shuyan,Miao, Hongyan,Ding, Yuqiang
, p. 1615 - 1621 (2015/02/19)
The simple ligand-free direct arylation of quinones with aryl halides applying Pd(OAc)2as a catalyst in accordance with Heck reaction was studied. This reaction provided a simple and efficient synthetic approach to efficient inhibitors of β-secretase aryl-substituted quinones.
Transition metal-free direct C-H functionalization of quinones and naphthoquinones with diaryliodonium salts: Synthesis of aryl naphthoquinones as β-secretase inhibitors
Wang, Dawei,Ge, Bingyang,Li, Liang,Shan, Jie,Ding, Yuqiang
, p. 8607 - 8613 (2015/01/08)
A novel ligand-free, transition metal-free direct C.H functionalization of quinones with diaryliodonium salts has been developed for the first time. The transformation was promoted only through the use of a base and gave aryl quinone derivatives in moderate to good yields. This methodology provided an effective and easy way to synthesize β-secretase inhibitors. The radical trapping experiments showed that this progress was the radical mechanism.
Synthesis of aryl- and alkylquinones through rhodium-catalyzed C-C coupling under mild conditions
Wang, Dawei,Ge, Bingyang,Du, Liyong,Miao, Hongyan,Ding, Yuqiang
supporting information, p. 2895 - 2898 (2015/02/02)
A direct arylation, alkylation of quinones with aryl and alkyl boronic acids through rhodium-catalyzed C-C coupling has been developed under mild conditions. [CpRhCl2]2 was shown to be the most effective catalyst for the transformation. More importantly, good to excellent yields were obtained under room temperature and base-free conditions. This reaction provides a practical, efficient method for the synthesis of aryl- and alkylquinones.
