70570-87-5Relevant academic research and scientific papers
Photochemical a-carboxyalkylation of tryptophols and tryptaminesviaC-H functionalization
Hu, Fengchi,Liu, Qinglong,Liu, Yuchang,Pan, Zhiqiang,Shang, Wenbin,Xia, Chengfeng
, p. 4930 - 4933 (2020)
A process for the a-carboxyalkylation of tryptophols and tryptamines by the functionalization of C-H bonds under visible light irradiation has been developed. The photochemical strategy activated the C-Br bonds of a-bromo-alkylcarboxylic esters to provide carbon-centered radicals under the catalysis of Ir(iii) photocatalyst and coupled with indole derivatives. This methodology displayed wide functional group tolerance and excellent regioselectivity, and was applied to the late-stage functionalization and preparation of indole-containing hybrids.
