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Usage

Uses

Used in Pharmaceutical Synthesis:
METHYL 4,4,4-TRIFLUOROCROTONATE is used as a key intermediate for the synthesis of various fluorinated pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved properties, such as enhanced bioavailability, increased stability, and better targeting of specific biological pathways.
Used in the Synthesis of Perfluromethylcoumarins:
METHYL 4,4,4-TRIFLUOROCROTONATE is used as a starting material for the synthesis of Perfluromethylcoumarins, a class of compounds with potential applications in the pharmaceutical industry. These compounds may exhibit interesting biological activities and could be further developed into new therapeutic agents.
Used in the Preparation of Regioisomeric (Trifluoromethyl)-isoxazolecarboxylate Esters:
METHYL 4,4,4-TRIFLUOROCROTONATE is used as a precursor for the preparation of regioisomeric (trifluoromethyl)-isoxazolecarboxylate esters. These esters are valuable building blocks for the synthesis of complex molecules and may have potential applications in the development of new drugs and pharmaceuticals.
Used in the Synthesis of Oxime Addition Products:
METHYL 4,4,4-TRIFLUOROCROTONATE is also used in the synthesis of oxime addition products, which are important intermediates in the preparation of various organic compounds. These products may have potential applications in the pharmaceutical, agrochemical, and materials science industries, contributing to the development of new products and technologies.

InChI:InChI=1/C5H5F3O2/c1-10-4(9)2-3-5(6,7)8/h2-3H,1H3/b3-2+

Upstream product

• 83961-54-0 methyl 4,4,4-trifluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate 

Downstream Products

• 104721-39-3 3-(2-Chloro-phenyl)-5-trifluoromethyl-isoxazole-4-carboxylic acid methyl ester 
• 104721-40-6 3-(2-Chloro-phenyl)-4-trifluoromethyl-isoxazole-5-carboxylic acid methyl ester 
• 135582-59-1 Methyl 3-perfluoromethyl-4-phenylbut-3-enoate 
• 135582-44-4 Methyl 3-perfluoromethyl-4-phenyl-4-triphenylphosphoranylidenebut-2-enoate 
• 135582-30-8 3-Perfluoromethyl-4-phenyl-2-triphenylphosphoranylidenebut-3-enoate 
• 135582-15-9 3-Perfluoromethyl-4-phenyl-2-triphenylphosphoranylidenebut-3-enoate 
• 135582-60-4 Methyl 4-(p-chlorophenyl)-3-perfluoromethylbut-3-enoate 
• 135582-45-5 Methyl 4-(p-chlorophenyl)-3-perfluoromethyl-4-triphenylphosphoranylidenebut-2-enoate 
• 135582-31-9 Methyl 4-(p-chlorophenyl)-3-perfluoromethyl-2-triphenylphosphoranylidenebut-3-enoate 
• 135582-16-0 Methyl 4-(p-chlorophenyl)-3-perfluoromethyl-2-triphenylphosphoranylidenebut-3-enoate 
• 135582-61-5 Methyl 4-(m-bromophenyl)-3-perfluoromethylbut-3-enoate 
• 135582-32-0 Methyl 4-(m-bromophenyl)-3-perfluoromethyl-2-triphenylphosphoranylidenebut-3-enoate 
• 135582-17-1 Methyl 4-(m-bromophenyl)-3-perfluoromethyl-2-triphenylphosphoranylidenebut-3-enoate 
• 143366-19-2 2-[(E)-3-Methoxycarbonyl-2-trifluoromethyl-1-(triphenyl-λ⁵-phosphanylidene)-allyl]-benzoic acid ethyl ester 

Relevant academic research and scientific papers

DABCO-catalyzed synthesis of trifluoromethylated furans from propargyl alcohols and methyl 2-perfluoroalkynoate

The DABCO-catalyzed reaction of propargyl alcohols with methyl 2-perfluoroalkynoate to give trifluoromethylated furans in up to 98% yield under mild conditions has been developed. The established allene-enol and control experiments indicate that the react

Fluorine segregation in crystalline materials: Structural control and solid-state [2+2] cycloaddition in CF3-substituted tetrathiafulvalene derivatives

The well-known influence of long perfluorinated chains on the structures and stability of amphiphilic molecules in liquid crystalline mesophases or mesoscopic micellar arrangements is evaluated here in the realm of crystalline materials based on rigid aro