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Usage

Uses

Used in Pharmaceutical Industry:
5-Chloroquinoline-8-carboxylic acid is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activities. It serves as a key component in the development of drugs targeting inflammation and tumor growth due to its anti-inflammatory and anti-tumor properties.
Used in Agrochemical Industry:
In the agrochemical sector, 5-chloroquinoline-8-carboxylic acid is utilized as an intermediate in the synthesis of agrochemicals. Its role is crucial in creating compounds that can protect crops from pests and diseases, thereby ensuring a stable food supply.
Used in Chemical Industry:
5-Chloroquinoline-8-carboxylic acid is employed as a building block in the chemical industry for the production of various organic compounds. Its unique structure allows it to be a versatile component in the synthesis of a wide range of chemical products, contributing to the diversity of applications in different industries.

Upstream product

• 56-81-5 glycerol 
• 89-77-0 2-Amino-4-chlorobenzoic acid 

Downstream Products

• 1438559-27-3 (5-chloroquinolin-8-yl)(phenyl)methanone 
• 1438559-55-7 1-(5-chloroquinolin-8-yl)ethanone 

Relevant academic research and scientific papers

Method for preparing 8-quinoline carboxylic acid and derivatives of 8-quinoline carboxylic acid

The invention discloses a method for preparing 8-quinoline carboxylic acid and derivatives thereof, which comprises the following steps: by using a compound I as a raw material, reacting with an oxidant at the temperature of 50-150 DEG C under normal pressure in a solvent under the action of a Cu-Co-X ternary composite catalyst to obtain a compound II; according to the method, the efficient Cu-Co-X ternary composite catalyst is adopted, the reaction is carried out at the temperature of 50-150 DEG C under normal pressure, the reaction condition is mild, the oxidation yield is remarkably increased, near-zero emission of three wastes is realized, the pollution problem is effectively solved, and the production cost is greatly reduced.

Catalytic formation of ketones from unactivated esters through rhodium chelation-assisted C-O bond activation

A new method for building aryl aryl ketones containing heterocyclic rings through chelation-assisted C-O bond activation catalyzed by a rhodium complex has been developed. In this reaction, methyl quinoline-8-carboxylate, methyl quinoxaline-5-carboxylate, and their derivatives were reacted with an excess amount of a substituted phenyl boronic acid in the presence of a rhodium(I) complex to give substituted phenyl(quinolin-8-yl)methanone, phenylquinoxalin-5- ylmethanone, and their derivatives in medium to high yields. The current method offers a highly favorable synthetic pathway to efficiently build related drugs with an 8-benzoylquinoline core structure. This method may prove especially valuable for medicinal chemists for the late-stage introduction of versatile ketone moieties into complex scaffolds for diversity-oriented synthetic strategies.

Direct exchange of a ketone methyl or aryl group to another aryl group through ciC bond activation assisted by rhodium chelation

Swapped: Commercially available quinolinone derivatives (1 or 2, see scheme) were reacted with arylboronic acids in the presence of a RhI complex to give aryl(quinolin-8-yl)methanone products 3 in medium to good yields. A mechanism that involves the in situ oxidation of RhI to RhIII by O2 in the presence of CuI was proposed. Copyright