70588-91-9

Usage

Chemical structure

A pyrazole derivative containing a 6-chloropyridazin-3-yl group and a 3-methyl-1H-pyrazol-5-amine group.

Usage

Commonly used in pharmaceutical research and development.

Potential applications

Utilized in the synthesis of various pharmaceutical drugs and compounds.

Pharmacological and biological activities

Not widely documented, but structural features suggest potential applications in medicinal chemistry and drug discovery.

Safety measures

Proper handling and safety measures should be followed when working with 1-(6-chloropyridazin-3-yl)-3-methyl-1H-pyrazol-5-amine to ensure the safety of researchers and the environment.

Upstream product

• 17284-97-8 3-Chloro-6-hydrazinopyridazine 
• 1118-60-1 3-iminobutyronitrile 

Relevant academic research and scientific papers

3-(1-Pyrazolyl)-pyridazine derivatives and hypotensive compositions thereof

The invention relates to compounds of general formula STR1 wherein R1 stands for a hydrogen atom or a C1-6 alkyl-, a C2-4 hydroxyalkyl, a C3-6 cycloalkyl or a phenyl group, R2 stands for a hydrogen, fluorine, chlorine or bromine atom or a C1-6 alkyl, a C2-4 hydroxyalkyl, a nitro or an --NR5 R6 group, wherein R5 and R6 may have the same or different meaning and stand each for a hydrogen atom or a C1-4 alkyl or a C2-4 hydroxyalkyl group, R3 stands for a hydrogen atom or a C1-6 alkyl, a C2-4 hydroxyalkyl, a C3-6 cycloalkyl or a phenyl group, a chlorine atom or a hydroxyl, amino or methoxy group, R4 stands for a carbamoyl, a cyano or an --NR7 --NHR8 group, wherein R7 and R8 may have the same or different meaning and stand each for a hydrogen atom or a C1-4 alkyl, a C2-4 hydroxyalkyl, a C1-4 alkoxycarbonyl or an --NR9 R10 group, wherein R9 and R10 may have the same or different meaning and stand each for a hydrogen atom or a C1-5 alkyl, a C2-4 hydroxyalkyl, a C3-6 cycloalkyl, a phenyl or a benzyl group, or --NR9 R10 may represent a morpholine, piperidine or piperazine ring, and their pharmaceutically acceptable acid-addition salts. Furthermore, the invention relates to a process for preparing these compounds. The novel compounds of general formula I have valuable pharmacological properties. Thus they show a considerable hypotensive effect and are capable to inhibit enzymes regulating the catabolism of prostaglandins.

Studies in the field of pyridazine compounds, III (1). Hypotensive 3-(1-pyrazolyl) pyridazine derivatives

Substituted 3-(1-pyrazolyl)pyridazines were synthesized and their hypotensive activity was evaluated on anaesthetized normotensive cats and awake spontaneously hypertensive rats. Several relations were found between structure and hypotensive activity of the compounds. Some of the active compounds proved to be useful for detailed investigations. Most of the active compounds exerted an influence on prostaglandin metabolism.